Publication Name	World Journal of Gastroenterology
Manuscript ID	11028
Country	China

Received	2014-05-01 09:03
Peer-Review Started	2014-05-02 11:33
To Make the First Decision	2014-05-29 19:01
Return for Revision	2014-06-04 16:25
Revised	2014-06-25 08:33
Second Decision	2014-07-16 12:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-16 13:12
Articles in Press	2014-07-16 17:57
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-22 21:35
Typeset the Manuscript	2014-10-15 11:32
Publish the Manuscript Online	2014-10-29 19:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Effect of Danshao Huaxian capsule on Gremlin and bone morphogenetic protein-7 expression in hepatic fibrosis in rats
Manuscript Source	Unsolicited Manuscript
All Author List	Xue-Ke Zhao, Ming-Liang Cheng, Rong-Min Wu, Yu-Mei Yao, Mao Mu, Juan-Juan Zhu, Bao-Fang Zhang and Ming-Yu Zhou
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Project of Guizhou Province, China SZ [2008] 3049
Corresponding Author	Ming-Liang Cheng, MD, Department of Infectious Diseases, Affiliated Hospital of Guiyang Medical College, No. 28, Guiyi Road, Guiyang 550004, Guizhou Province, China. chengml@21cn.com
Key Words	Hepatic fibrosis; Bone morphogenetic protein; Gremlin; Transforming growth factor; Traditional Chinese herbs
Core Tip	Hepatic fibrosis, as a refractory disease, represents a current threat to global health. To date, no ideal drug therapies have been identified, and drugs for liver fibrosis remain in the exploratory stage of development. Previous experimental and clinical studies showed that Danshao Huaxian capsule (DHC, originally called Handan Ganle) demonstrated efficacy in treating liver fibrosis. In this study, the effect of DHC on the expression of Gremlin and bone morphogenetic protein 7 (BMP-7) in a liver fibrosis rat model was observed to explore its potential mechanism for treating liver fibrosis. We found that the therapeutic mechanism of DHC for hepatic fibrosis in rats may be associated with inhibition of the expression of Gremlin and up-regulation of the expression of BMP-7.
Publish Date	2014-10-29 19:34
Citation	Zhao XK, Cheng ML, Wu RM, Yao YM, Mu M, Zhu JJ, Zhang BF, Zhou MY. Effect of Danshao Huaxian capsule on Gremlin and bone morphogenetic protein-7 expression in hepatic fibrosis in rats. World J Gastroenterol 2014; 20(40): 14875-14883
URL	http://www.wjgnet.com/1007-9327/full/v20/i40/14875.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i40.14875

Full Article (PDF)	WJG-20-14875.pdf
Full Article (Word)	WJG-20-14875.doc
Manuscript File	11028-Review.doc
Answering Reviewers	11028-Answering reviewers.pdf
Copyright License Agreement	11028-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11028-Language certificate.pdf
Peer-review Report	11028-Peer reviews.pdf
Scientific Misconduct Check	11028-CrossCheck.jpg
Scientific Editor Work List	11028-Scientific editor work list.pdf