Publication Name	World Journal of Diabetes
Manuscript ID	110285
Country	China

Received	2025-06-04 03:29
Peer-Review Started	2025-06-04 09:56
To Make the First Decision
Return for Revision	2025-06-11 03:40
Revised	2025-06-15 14:04
Second Decision	2025-07-14 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-14 08:51
Articles in Press	2025-07-14 08:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-01 13:59
Publish the Manuscript Online	2025-08-14 10:52

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Letter to the Editor
Article Title	Microglial metabolic reprogramming: Aucubin inhibits aldose reductase to reverse diabetic neuropathic pain
Manuscript Source	Invited Manuscript
All Author List	Bin Li
ORCID	Author(s) ORCID Number Bin Li http://orcid.org/0000-0003-2882-7512
Funding Agency and Grant Number	Funding Agency Grant Number Top-level Talents Support Program of Yangzhou University “Lv Yang Jin Feng” Outstanding Doctor of Yangzhou No. YZLYJFJH2023YXBS169 Natural Science Foundation of Jiangsu Province No. BK20240907
Corresponding Author	Bin Li, Full Professor, PhD, Institution of Compared Medicine, Yangzhou University, No. 88 South Daxue Road, Yangzhou 225009, Jiangsu Province, China. lib111701@163.com; 008480@yzu.edu.cn
Key Words	Diabetic neuropathic pain; Microglia; Metabolism; Aldose reductase; Neuroinflammation
Core Tip	Zheng et al have uncovered a new anti-neuropathic function of the plant glycoside aucubin-inhibiting aldose reductase and thus preventing hyperglycaemia-driven microglial aerobic glycolysis and inflammation associated with diabetic neuropathy. This study highlights a novel metabolism-immunity axis of diabetic neuropathic pain and offers an innovative therapeutic strategy.
Publish Date	2025-08-14 10:52
Citation	<p>Li B. Microglial metabolic reprogramming: Aucubin inhibits aldose reductase to reverse diabetic neuropathic pain. <i>World J Diabetes</i> 2025; 16(8): 110285</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i8/110285.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i8.110285

Full Article (PDF)	WJD-16-110285-with-cover.pdf
Manuscript File	110285_Auto_Edited_065014.docx
Answering Reviewers	110285-answering-reviewers.pdf
Audio Core Tip	110285-audio.mp3
Conflict-of-Interest Disclosure Form	110285-conflict-of-interest-statement.pdf
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Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	110285-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	110285-non-native-speakers.pdf
Peer-review Report	110285-peer-reviews.pdf
Scientific Misconduct Check	110285-scientific-misconduct-check.png
Scientific Editor Work List	110285-scientific-editor-work-list.pdf
CrossCheck Report	110285-crosscheck-report.pdf