Publication Name	World Journal of Clinical Cases
Manuscript ID	110330
Country	South Korea

Received	2025-06-11 08:55
Peer-Review Started	2025-06-11 08:56
To Make the First Decision
Return for Revision	2025-06-22 10:43
Revised	2025-07-04 09:43
Second Decision	2025-08-12 02:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-13 10:10
Articles in Press	2025-08-13 10:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-09-15 07:23
Publish the Manuscript Online	2025-10-11 09:30

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Case Report
Article Title	Spontaneous colonic transection following pathologic complete response to pembrolizumab in high microsatellite instability colorectal cancer: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Chungyeop Lee, Min Hyun Kim, Eu-Tteum Choi, In Ja Park, Seok-Byung Lim, Yong Sik Yoon, Chan Wook Kim, Jong Lyul Lee and Eun Jung Park
ORCID	Author(s) ORCID Number Chungyeop Lee http://orcid.org/0000-0003-4119-4035 Min Hyun Kim http://orcid.org/0000-0002-9414-7817 Eu-Tteum Choi http://orcid.org/0000-0003-0499-1692 In Ja Park http://orcid.org/0000-0001-5355-3969 Seok-Byung Lim http://orcid.org/0000-0001-8824-4808 Yong Sik Yoon http://orcid.org/0000-0002-3196-8423 Chan Wook Kim http://orcid.org/0000-0002-2382-0939 Jong Lyul Lee http://orcid.org/0000-0002-5878-8000 Eun Jung Park http://orcid.org/0000-0002-4559-2690
Funding Agency and Grant Number
Corresponding Author	Min Hyun Kim, MD, Division of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea. mhjerrykim@gmail.com
Key Words	Pembrolizumab; Colon cancer; High microsatellite instability; Mismatch repair deficient; Transection; Case report
Core Tip	We report here the first case of spontaneous colonic transection in a patient with high microsatellite instability colon cancer who achieved pathologic complete response after long-term pembrolizumab therapy. Despite no residual tumor on imaging or pathology, intraoperative findings revealed a discontinuity of the bowel at the original tumor site. Immune-mediated remodeling can compromise bowel integrity and may not be apparent on imaging. Clinicians should consider potential anatomic changes when planning surgery in patients treated with immunotherapy, even in the context of a complete response.
Publish Date	2025-10-11 09:30
Citation	<p>Lee C, Kim MH, Choi ET, Park IJ, Lim SB, Yoon YS, Kim CW, Lee JL, Park EJ. Spontaneous colonic transection following pathologic complete response to pembrolizumab in high microsatellite instability colorectal cancer: A case report and review of literature. <i>World J Clin Cases</i> 2025; 13(30): 110330</p>
URL	https://www.wjgnet.com/2307-8960/full/v13/i30/110330.htm
DOI	https://dx.doi.org/10.12998/wjcc.v13.i30.110330

Full Article (PDF)	WJCC-13-110330-with-cover.pdf
CARE Checklist–2016	110330-CARE-Checklist-2016.pdf
Manuscript File	110330_Auto_Edited_052212.docx
Answering Reviewers	110330-answering-reviewers.pdf
Audio Core Tip	110330-audio.mp3
Conflict-of-Interest Disclosure Form	110330-conflict-of-interest-statement.pdf
Copyright License Agreement	110330-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s)	110330-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	110330-non-native-speakers.pdf
Peer-review Report	110330-peer-reviews.pdf
Scientific Misconduct Check	110330-scientific-misconduct-check.png
Scientific Editor Work List	110330-scientific-editor-work-list.pdf
CrossCheck Report	110330-crosscheck-report.pdf