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Articles Published Processes
11/21/2025 5:52:40 AM | Browse: 5 | Download: 43
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Received |
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2025-06-05 14:45 |
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Peer-Review Started |
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2025-06-05 14:45 |
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To Make the First Decision |
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Return for Revision |
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2025-07-08 07:04 |
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Revised |
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2025-07-19 15:45 |
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Second Decision |
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2025-09-23 02:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-23 07:20 |
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Articles in Press |
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2025-09-23 07:20 |
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Publication Fee Transferred |
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2025-07-24 13:17 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-18 05:17 |
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Publish the Manuscript Online |
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2025-11-21 05:52 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Role of SOX9 in cardiovascular diseases: Evidence today
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Angat Naresh Chadha, Han Cheng and Jing Yang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82200353 |
| Jiangsu Province Double Innovation Doctoral Program |
No. JSSCBS20221948 |
| Suzhou Gusu Health Talent Program |
No. (2022)043 |
| Suzhou Gusu Health Talent Plan Talent Research Project |
No. GSWS2022014 |
| Suzhou Science and Technology Innovation Policy Funding Project, the Jiangsu Province College Students’ Innovation and Entrepreneurship Training Program Project |
No. 202410285087Z |
| Multi-center Clinical Research Project for Major Diseases in Suzhou |
No. DZXYJ202302 |
| “Bo Xi” Talent Casting Plan of the First Affiliated Hospital of Soochow University |
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| Corresponding Author |
Jing Yang, PhD, Department of Cardiology, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou 215006, Jiangsu Province, China. jingyang_cardio@163.com |
| Key Words |
SRY-related high-mobility group box 9; Endocardial cushion; Heart valves; Myocardial fibrosis; Transcription factors |
| Core Tip |
This article synthesizes evidence revealing the dual roles of SRY-related high-mobility group box 9 (SOX9) in cardiovascular biology. Crucially, SOX9 is indispensable for embryonic heart development, governing valve formation and atrioventricular septation. In adult cardiovascular diseases, SOX9 acts as a key pathogenic driver: It promotes myocardial fibrosis and extracellular matrix remodeling, inhibits valve calcification, contributes to pulmonary hypertension, and accelerates vascular aging and remodeling. Its disease-specific regulatory mechanisms position SOX9 as a promising therapeutic target across diverse cardiovascular disorders. |
| Publish Date |
2025-11-21 05:52 |
| Citation |
<p>Chadha AN, Cheng H, Yang J. Role of SOX9 in cardiovascular diseases: Evidence today. <i>World J Cardiol</i> 2025; 17(11): 110339</p> |
| URL |
https://www.wjgnet.com/1949-8462/full/v17/i11/110339.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v17.i11.110339 |
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