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Articles Published Processes
2/10/2026 10:35:43 AM | Browse: 1 | Download: 11
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Received |
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2025-06-05 14:29 |
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Peer-Review Started |
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2025-06-05 14:29 |
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First Decision by Editorial Office Director |
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2025-06-17 09:22 |
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Return for Revision |
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2025-06-17 09:22 |
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Revised |
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2025-06-28 17:57 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-22 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-22 07:31 |
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Articles in Press |
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2025-09-22 07:31 |
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Edit the Manuscript by Language Editor |
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2025-09-28 23:09 |
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Typeset the Manuscript |
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2026-01-30 08:08 |
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Publish the Manuscript Online |
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2026-02-10 10:35 |
| ISSN |
2222-0682 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Minireviews |
| Article Title |
Update on hypoxic-ischemic brain injury: Prognosis and management
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ajaya Kumar Ayyappan Unnithan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ajaya Kumar Ayyappan Unnithan, Assistant Professor, Department of Neurosurgery, Azeezia Medical College Hospital, Department of Neurosurgery, Azeezia Medical College, Kerala, India. Electronic address: drajayakumara@gmail.com., Kollam 691537, Kerala, India. drajayakumara@gmail.com |
| Key Words |
Brain hypoxia-ischemia; Cerebral autoregulation; Post-cardiac arrest syndrome; Targeted temperature management; Diffusion-weighted imaging; Neuron-specific enolase; Multimodal prognostication; Persistent vegetative state |
| Core Tip |
The indicators of good prognosis in hypoxic-ischemic brain injury (HIBI) are: An early return of continuous and reactive electroencephalogram, low blood levels of neuron specific enolase, absence of diffusion changes in brain magnetic resonance imaging, good functional status, and Coma Remission Scale scores of 8 and more. The treatment consists of maintaining systemic perfusion, treatment of the underlying cause of the hypoxia, and prevention of ongoing brain injury. HIBI is a major cause of mortality and the outcome after survival may vary from persistent vegetative state to neuropsychiatric disabilities. |
| Publish Date |
2026-02-10 10:35 |
| Citation |
Ayyappan Unnithan AK. Update on hypoxic-ischemic brain injury: Prognosis and management. World J Methodol 2026; 16(1): 110342 |
| URL |
https://www.wjgnet.com/2222-0682/full/v16/i1/110342.htm |
| DOI |
https://dx.doi.org/10.5662/wjm.v16.i1.110342 |
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