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Articles Published Processes
11/6/2025 8:56:36 AM | Browse: 78 | Download: 267
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Received |
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2025-06-10 10:08 |
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Peer-Review Started |
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2025-06-10 10:08 |
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First Decision by Editorial Office Director |
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2025-08-11 07:27 |
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Return for Revision |
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2025-08-11 07:27 |
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Revised |
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2025-09-02 02:57 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-28 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-28 08:09 |
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Articles in Press |
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2025-09-28 08:09 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-28 03:04 |
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Publish the Manuscript Online |
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2025-11-06 08:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Pescadillo ribosomal biogenesis factor 1 as a therapeutic target in tumor immunotherapy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia Yu, Bo Yu, Fei-Lin Ge and Zhi-Gang Ren |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82470654 |
| Natural Science Foundation Key Project of Henan Province |
232300421124 |
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| Corresponding Author |
Zhi-Gang Ren, Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, the First Affiliated Hospital of Zhengzhou University, Jianshe East Road, Zhengzhou 450052, Henan Province, China. fccrenzg@zzu.edu.cn |
| Key Words |
Pescadillo ribosomal biogenesis factor 1; Programmed death-ligand 1; Tumor immune evasion; Tumor immunotherapy; Immune evasion mechanisms |
| Core Tip |
In gastric cancer and head and neck squamous cell carcinoma, pescadillo ribosomal biogenesis factor 1 (PES1) and programmed death-ligand 1 (PD-L1) show significant co-expression. Across multiple tumor types, elevated PES1 is linked to poor prognosis and aggressive tumor behavior. Our analysis further reveals that PES1 expression negatively correlates with CD8+ T cell infiltration and positively correlates with PD-L1 expression. These findings suggest opportunities for combination cancer immunotherapy, although the molecular basis of PES1-PD-L1 interactions and the therapeutic benefit of dual targeting require further experimental validation. |
| Publish Date |
2025-11-06 08:56 |
| Citation |
Yu J, Yu B, Ge FL, Ren ZG. Pescadillo ribosomal biogenesis factor 1 as a therapeutic target in tumor immunotherapy. World J Gastroenterol 2025; 31(41): 110367 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i41/110367.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i41.110367 |
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