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Articles Published Processes
12/19/2025 8:32:38 AM | Browse: 2 | Download: 2
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Received |
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2025-06-06 13:21 |
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Peer-Review Started |
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2025-06-06 13:21 |
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First Decision by Editorial Office Director |
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2025-06-17 09:21 |
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Return for Revision |
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2025-06-17 09:21 |
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Revised |
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2025-06-21 17:12 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-05 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-05 07:42 |
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Articles in Press |
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2025-09-05 07:42 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-08 09:25 |
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Publish the Manuscript Online |
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2025-12-19 08:32 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Dentistry, Oral Surgery & Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Immunohistochemical expression of epithelial mesenchymal transition proteins ZEB1 and E-cadherin in oral leukoplakia and oral squamous cell carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Gouri S Panchannavar and Punnya V Angadi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Punnya V Angadi, Deputy Director, Full Professor, MD, Department of Oral and Maxillofacial Pathology, KLE VK Institute of Dental Sciences, KLE Academy of Higher Education and Research, JNMC Campus, Nehrunagar, Belagavi 580010, Karnataka, India. punnya_angadi@rediffmail.com |
| Key Words |
Oral squamous cell carcinoma; Oral leukoplakia; Oral epithelial dysplasia; Epithelial mesenchymal transition; E-cadherin; Zinc-finger E-box-binding homeobox 1 |
| Core Tip |
The study demonstrates the presence of the epithelial-mesenchymal transition (EMT) phenomenon in oral premalignant and malignant lesions suggesting it to be an early change in carcinogenesis. The loss of E-cadherin and up-regulation of zinc-finger E-box-binding homeobox 1 from oral epithelial dysplasia to oral squamous cell carcinoma corresponds to its role in the induction of EMT and correlated to regional lymph node metastasis, thus promoting tumor progression, invasion, and metastasis. Discriminant formulas have been established to ascertain the malignant potential and to categorize instances of oral epithelial dysplasia and oral squamous cell carcinoma based on the expression of EMT markers which is not previously reported. |
| Publish Date |
2025-12-19 08:32 |
| Citation |
Panchannavar GS, Angadi PV. Immunohistochemical expression of epithelial mesenchymal transition proteins ZEB1 and E-cadherin in oral leukoplakia and oral squamous cell carcinoma. World J Exp Med 2025; 15(4): 110372 |
| URL |
https://www.wjgnet.com/2220-315x/full/v15/i4/110372.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i4.110372 |
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