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Articles Published Processes
10/31/2025 3:03:02 PM | Browse: 47 | Download: 172
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Received |
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2025-06-06 16:53 |
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Peer-Review Started |
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2025-06-06 16:53 |
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First Decision by Editorial Office Director |
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2025-06-17 09:30 |
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Return for Revision |
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2025-06-17 09:30 |
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Revised |
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2025-06-29 01:06 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-18 02:54 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-18 04:32 |
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Articles in Press |
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2025-09-18 04:32 |
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Edit the Manuscript by Language Editor |
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2025-09-25 00:01 |
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Typeset the Manuscript |
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2025-10-20 02:01 |
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Publish the Manuscript Online |
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2025-10-31 15:03 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Minireviews |
| Article Title |
Impact of glucocorticoid therapy on hypothalamic-pituitary-adrenal axis function in pediatric nephrotic syndrome: A narrative review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Subhankar Sarkar, Asiri Samantha Abeyagunawardena and Rajiv Sinha |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Rajiv Sinha, Division of Paediatric Nephrology, Institute of Child Health, Biresh Guha Street, Kolkata 700 017, India. rajivsinha_in@yahoo.com |
| Key Words |
Glucocorticoids; Hypothalamic-pituitary-adrenal axis; Adrenal insufficiency; Nephrotic syndrome; Prednisolone; Cortisol; Hypothalamic-pituitary-adrenal axis suppression; Steroid therapy; Low-dose Synacthen test |
| Core Tip |
Children with nephrotic syndrome often require repeated glucocorticoid therapy, which can lead to hypothalamic-pituitary-adrenal axis suppression and secondary adrenal insufficiency. This impaired stress response may contribute to relapse during infections. This review summarizes the mechanisms, diagnostic methods, clinical implications, and preventive strategies, underscoring the need for early identification and tailored steroid management to reduce long-term risks. |
| Publish Date |
2025-10-31 15:03 |
| Citation |
Sarkar S, Abeyagunawardena AS, Sinha R. Impact of glucocorticoid therapy on hypothalamic-pituitary-adrenal axis function in pediatric nephrotic syndrome: A narrative review. World J Clin Pediatr 2025; 14(4): 110374 |
| URL |
https://www.wjgnet.com/2219-2808/full/v14/i4/110374.htm |
| DOI |
https://dx.doi.org/10.5409/wjcp.v14.i4.110374 |
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