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Articles Published Processes
12/11/2025 8:20:56 AM | Browse: 6 | Download: 1
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Received |
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2025-06-10 02:44 |
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Peer-Review Started |
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2025-06-10 02:45 |
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First Decision by Editorial Office Director |
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2025-07-08 09:39 |
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Return for Revision |
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2025-07-09 06:31 |
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Revised |
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2025-07-22 10:51 |
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Publication Fee Transferred |
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2025-07-26 05:43 |
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Second Decision by Editor |
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2025-10-23 02:32 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-23 09:00 |
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Articles in Press |
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2025-10-23 09:00 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-02 00:35 |
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Publish the Manuscript Online |
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2025-12-11 08:20 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Cancer-associated fibroblasts, clinicopathological characteristics and prognosis of liver cancer: A systematic review and meta-analysis based on real-world research
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Hao Wei, Wen-Jing Jiang, Shi-Qian Wang, Yu-Long Cai and Xue-Lei Ma |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Sichuan Science and Technology Program |
No. 2024NSFSC1936 |
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| Corresponding Author |
Xue-Lei Ma, Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan Province, China. drmaxuelei@gmail.com |
| Key Words |
Cancer-associated fibroblasts; Liver neoplasms; Prognosis; Liver cancer; Meta-analysis |
| Core Tip |
This meta-analysis reveals that high expression of cancer-associated fibroblasts (CAFs), particularly marked by α-smooth muscle actin, is significantly associated with poor overall survival in liver cancer, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma. CAFs serve as a robust prognostic biomarker, with stronger predictive value in hepatocellular carcinoma. While their impact on clinicopathological features remains inconclusive, these findings highlight CAFs as potential therapeutic targets. Further research is needed to clarify their role in tumor progression and optimize clinical applications. |
| Publish Date |
2025-12-11 08:20 |
| Citation |
Wei YH, Jiang WJ, Wang SQ, Cai YL, Ma XL. Cancer-associated fibroblasts, clinicopathological characteristics and prognosis of liver cancer: A systematic review and meta-analysis based on real-world research. World J Gastrointest Oncol 2025; 17(12): 110395 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i12/110395.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i12.110395 |
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