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Articles Published Processes
8/7/2025 6:39:58 AM | Browse: 99 | Download: 434
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Received |
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2025-06-07 03:29 |
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Peer-Review Started |
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2025-06-07 03:30 |
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First Decision by Editorial Office Director |
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2025-06-12 08:35 |
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Return for Revision |
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2025-06-12 08:35 |
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Revised |
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2025-06-26 01:41 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-07-21 02:57 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-07-21 05:50 |
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Articles in Press |
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2025-07-21 05:50 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-04 01:54 |
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Publish the Manuscript Online |
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2025-08-07 06:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Serum metabolomic characteristics and their predictive value for ninety-day prognosis in patients with acute-on-chronic liver failure
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan Liu, Ying Xiao, Lian-Feng Ai, Jing-Jing Zhang, Jian-Dong Zhang, Ze-Qiang Qi, Lei Dong and Ya-Dong Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hebei Natural Science Foundation |
No. H2023206042 |
| Medical Science Research Project of Hebei |
No. 20230670 |
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| Corresponding Author |
Ya-Dong Wang, Department of Infectious Diseases, The Hebei Medical University Third Hospital, No. 275 Zhongshan West Road, Qiaoxi District, Shijiazhuang 050000, Hebei Province, China. wangyadong@hebmu.edu.cn |
| Key Words |
Acute-on-chronic liver failure; Metabolomics; Artificial liver blood purification system; Modeling; Prognosis |
| Core Tip |
Acute-on-chronic liver failure (ACLF) is a rapidly progressing condition with high mortality and limited treatment options. Traditional prognostic models fail to capture its dynamic metabolic disturbances. This study identifies seven key metabolites linked to 90-day ACLF prognosis, with Arginine as an independent risk factor. Age- neutrophil-to-lymphocyte ratio-arginine model expressed perfect predictive efficiency for 90-day prognosis of patients with ACLF. In addition, artificial liver blood purification system treatment modulated alanine and L-carnitine, reducing inflammation and promoting liver regeneration. These findings highlight the potential of metabolomics to enhance ACLF prognosis, offering a more precise approach for clinical assessment and management. |
| Publish Date |
2025-08-07 06:39 |
| Citation |
Liu Y, Xiao Y, Ai LF, Zhang JJ, Zhang JD, Qi ZQ, Dong L, Wang YD. Serum metabolomic characteristics and their predictive value for ninety-day prognosis in patients with acute-on-chronic liver failure. World J Gastroenterol 2025; 31(30): 110401 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i30/110401.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i30.110401 |
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