Publication Name	World Journal of Hepatology
Manuscript ID	110430
Country	Ethiopia

Received	2025-06-07 01:29
Peer-Review Started	2025-06-07 01:29
To Make the First Decision
Return for Revision	2025-06-10 06:57
Revised	2025-06-19 14:22
Second Decision	2025-08-22 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-22 05:37
Articles in Press	2025-08-22 05:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-10-17 06:17
Publish the Manuscript Online	2025-10-27 10:57

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Sex-related differences in treatment outcomes of chronic hepatitis C with direct-acting antivirals
Manuscript Source	Invited Manuscript
All Author List	Gemechu Dereje Feyissa
ORCID	Author(s) ORCID Number Gemechu Dereje Feyissa http://orcid.org/0009-0009-9248-4084
Funding Agency and Grant Number
Corresponding Author	Gemechu Dereje Feyissa, Assistant Professor, Department of Public Health, Faculty of Health Sciences, Rift Valley University, Hangatu District, Dabe Sub-city, Adama 1715, Oromīa, Ethiopia. gemechudereje80@gmail.com
Key Words	Chronic hepatitis C; Direct-acting antivirals; Hepatitis C virus; Infection; Menopause; Outcomes; Sex-related differences; Treatment; Women
Core Tip	Sex influences the epidemiology, progression, and treatment outcomes of chronic hepatitis C. Women exhibit lower body mass index, less genotype 3 infection, and fewer hepatitis B virus/human immunodeficiency virus coinfections compared to men. They have slower liver fibrosis progression and achieve higher sustained virologic response rates with direct-acting antivirals. However, postmenopausal women report more treatment-related adverse events. Recognizing these sex- and reproductive status-related differences is crucial to optimize personalized management and improve therapeutic outcomes in chronic hepatitis C patients.
Publish Date	2025-10-27 10:57
Citation	<p>Feyissa GD. Sex-related differences in treatment outcomes of chronic hepatitis C with direct-acting antivirals. <i>World J Hepatol</i> 2025; 17(10): 110430</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i10/110430.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i10.110430

Full Article (PDF)	WJH-17-110430-with-cover.pdf
Manuscript File	110430_Auto_Edited_033808.docx
Answering Reviewers	110430-answering-reviewers.pdf
Audio Core Tip	110430-audio.m4a
Conflict-of-Interest Disclosure Form	110430-conflict-of-interest-statement.pdf
Copyright License Agreement	110430-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	110430-non-native-speakers.pdf
Peer-review Report	110430-peer-reviews.pdf
Scientific Misconduct Check	110430-scientific-misconduct-check.png
Scientific Editor Work List	110430-scientific-editor-work-list.pdf
CrossCheck Report	110430-crosscheck-report.pdf