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12/25/2025 9:13:54 AM | Browse: 0 | Download: 0
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Received |
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2025-06-06 16:54 |
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Peer-Review Started |
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2025-06-06 16:55 |
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First Decision by Editorial Office Director |
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2025-06-25 09:27 |
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Return for Revision |
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2025-06-25 09:27 |
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Revised |
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2025-08-12 21:51 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-19 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-19 06:34 |
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Articles in Press |
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2025-09-19 06:34 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-19 01:15 |
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Publish the Manuscript Online |
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2025-12-25 09:13 |
| ISSN |
2220-3249 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Minireviews |
| Article Title |
Comparison of three pediatric studies investigating acute hepatitis of unknown etiology
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Haruki Komatsu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Haruki Komatsu, MD, PhD, Department of Pediatrics, Komatsu Children’s Clinic, 4-2-1 Midorigaoka-nishi, Yachiyo 276-0040, Chiba, Japan. haruki-komatsu@chive.ocn.ne.jp |
| Key Words |
Adeno-associated virus; Cidofovir; Coinfection; Helper virus; Herpes virus; Human adenovirus; Human leukocyte antigen; Metagenomic sequencing; Phylogenetic tree analysis; Real-time PCR |
| Core Tip |
The rate of positivity for adeno-associated virus serotype 2 (AAV-2) was 80% or greater in cases of acute hepatitis of unknown etiology (AHUE) according to metagenomic sequencing and real-time polymerase chain reaction. AAV-2 RNA was detected in the nuclei and cytoplasm of ballooned hepatocytes through in situ hybridization. No distinct clade was observed in the phylogenetic tree analysis of whole genomes of AAV-2 isolated from cases. Coinfection of AAV-2 with one or more helper viruses (HAdV, HHV-6B, EBV, etc.), a high viral load of AAV-2 in blood, anti-AAV-2 IgM and human leukocyte antigen (HLA) typing (HLA-DRB1*04: 01, HLA-DQA1*03: 03 and HLA-DRB4*01: 03) could be candidate diagnostic criteria for AHUE. |
| Publish Date |
2025-12-25 09:13 |
| Citation |
Komatsu H. Comparison of three pediatric studies investigating acute hepatitis of unknown etiology. World J Virol 2025; 14(4): 110435 |
| URL |
https://www.wjgnet.com/2220-3249/full/v14/i4/110435.htm |
| DOI |
https://dx.doi.org/10.5501/wjv.v14.i4.110435 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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