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Articles Published Processes
11/13/2025 6:51:09 AM | Browse: 1 | Download: 0
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Received |
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2025-06-10 03:01 |
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Peer-Review Started |
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2025-06-10 03:02 |
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To Make the First Decision |
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Return for Revision |
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2025-07-07 06:23 |
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Revised |
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2025-07-20 10:07 |
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Second Decision |
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2025-10-10 02:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-10-10 05:44 |
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Articles in Press |
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2025-10-10 05:44 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-30 09:46 |
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Publish the Manuscript Online |
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2025-11-13 06:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Health Care Sciences & Services |
| Manuscript Type |
Minireviews |
| Article Title |
Hepatoprotective effects of silybin in liver fibrosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Xin Liu, Waseem Hassan, Hammad Ahmed and Shao-Zheng Song |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Shao-Zheng Song, Department of Pharmacy, School of Health and Nursing, Wuxi Taihu University, No. 68 Qianrong Road, Wuxi 214064, Jiangsu Province, China. ssz0610@163.com |
| Key Words |
Fibrosis; Inflammation; Kupffer cells; Liver; Silybin |
| Core Tip |
Liver fibrosis, a wound-healing response to chronic hepatic injury, is driven by redox-sensitive pathways, reactive oxygen species, and pro-fibrogenic cytokines like transforming growth factor-β. Silybum marianum (milk thistle), particularly its active compound silybin, exhibits promising antioxidant and anti-fibrotic properties. This study explores the biochemical oxidative mechanisms behind fibrogenesis and highlights silibin’s potential in reversing liver fibrosis through inhibition of oxidative stress and fibrogenic signaling pathways. |
| Publish Date |
2025-11-13 06:51 |
| Citation |
<p>Liu XX, Hassan W, Ahmed H, Song SZ. Hepatoprotective effects of silybin in liver fibrosis. <i>World J Gastroenterol</i> 2025; 31(42): 110449</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i42/110449.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i42.110449 |
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