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Articles Published Processes
11/21/2025 7:06:14 AM | Browse: 4 | Download: 39
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Received |
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2025-06-09 08:18 |
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Peer-Review Started |
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2025-06-09 08:18 |
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To Make the First Decision |
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Return for Revision |
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2025-07-08 07:27 |
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Revised |
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2025-07-21 11:23 |
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Second Decision |
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2025-10-27 02:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-10-27 09:26 |
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Articles in Press |
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2025-10-27 09:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-10-29 02:33 |
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Typeset the Manuscript |
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2025-11-17 01:25 |
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Publish the Manuscript Online |
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2025-11-21 07:06 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Gastric organoids: A promising model for studying “inflammation-cancer” transition in atrophic gastritis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chang Liu, Chen-Heng Wu, Yue-Bo Jia, Jun-Xin Qiu, Xin-Yuan Li and Jiang-Hong Ling |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Traditional Chinese Medicine Advantageous Specialty Project of National Administration of Traditional Chinese Medicine |
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| Shuguang Hospital Siming Foundation Research Special Project |
SGKJ-202304 |
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| Corresponding Author |
Jiang-Hong Ling, Department of Gastroenterology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 185 Pu’an Road, Huangpu District, Shanghai 201203, China. ljh18817424778@163.com |
| Key Words |
Gastric organoids; Atrophic gastritis; Inflammation-cancer transition; Gastric cancer; Helicobacter pylori; Tumor microenvironment; Spasmolytic polypeptide-expressing metaplasia |
| Core Tip |
Existing models are difficult to simulate the complex process of atrophic gastritis to gastric cancer, and gastric organoid technology provides a more accurate platform for studying this mechanism. Helicobacter pylori infection triggers activation of key oncogenic signaling pathways, DNA damage, and epigenetic alterations through its virulence factors and induced persistent inflammation. The gradual development of intestinal metaplasia and spasmodic polypeptide metaplasia accelerates the completion of inflammation-cancer transition under the combined action of tumor microenvironment of immunosuppression, metabolic abnormalities and matrix remodeling. The gastric organoid model successfully simulated the spatiotemporal dynamics of inflammation-cancer transition, and provides a powerful in vitro research platform. |
| Publish Date |
2025-11-21 07:06 |
| Citation |
<p>Liu C, Wu CH, Jia YB, Qiu JX, Li XY, Ling JH. Gastric organoids: A promising model for studying “inflammation-cancer” transition in atrophic gastritis. <i>World J Clin Oncol</i> 2025; 16(11): 110453</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i11/110453.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i11.110453 |
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