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Articles Published Processes
10/14/2025 7:42:32 AM | Browse: 29 | Download: 112
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Received |
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2025-06-10 01:46 |
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Peer-Review Started |
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2025-06-10 01:46 |
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First Decision by Editorial Office Director |
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2025-07-01 02:56 |
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Return for Revision |
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2025-07-01 02:56 |
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Revised |
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2025-07-13 14:36 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-08-14 03:14 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-08-14 13:30 |
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Articles in Press |
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2025-08-14 13:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-08 09:28 |
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Publish the Manuscript Online |
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2025-10-14 07:42 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Editorial |
| Article Title |
Uridine diphosphate-glucose 6-dehydrogenase-mediated glucuronidation and its emerging role in gut-liver immune regulation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ye-Qiu Yang, Ning Li, Shuai Liu and Yong-Wei Yu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yong-Wei Yu, PhD, Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. yuyongwei@zju.edu.cn |
| Key Words |
Uridine diphosphate-glucose 6-dehydrogenase; Glucuronidation; Gut-liver axis; Hepatocellular carcinoma; Immune microenvironment |
| Core Tip |
Uridine diphosphate-glucose 6-dehydrogenase (UGDH), a key metabolic enzyme involved in glucuronidation, is increasingly recognized for its role in hepatocellular carcinoma progression. Recent studies have revealed that dysregulated UGDH contributes not only to metabolic reprogramming but also to immune suppression by disrupting bile acid detoxification and facilitating microbial translocation from the gut. This editorial highlights the dual function of UGDH as both a metabolic and immune modulator, and introduces a novel hypothesis that positions UGDH as a potential checkpoint within the gut-liver immune axis. Understanding this interplay could lead to new therapeutic strategies targeting metabolic-immune cross-talk in gastrointestinal oncology. |
| Publish Date |
2025-10-14 07:42 |
| Citation |
Yang YQ, Li N, Liu S, Yu YW. Uridine diphosphate-glucose 6-dehydrogenase-mediated glucuronidation and its emerging role in gut-liver immune regulation. World J Gastrointest Oncol 2025; 17(10): 110464 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i10/110464.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i10.110464 |
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