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Articles Published Processes
10/24/2025 6:10:13 AM | Browse: 5 | Download: 44
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Received |
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2025-06-09 06:02 |
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Peer-Review Started |
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2025-06-09 06:02 |
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To Make the First Decision |
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Return for Revision |
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2025-06-18 07:24 |
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Revised |
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2025-07-03 09:34 |
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Second Decision |
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2025-09-23 02:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-23 06:57 |
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Articles in Press |
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2025-09-23 06:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-16 01:08 |
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Publish the Manuscript Online |
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2025-10-24 06:10 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Minireviews |
| Article Title |
Expansion strategies for Vδ2 γδT cells in cancer immunotherapy: Activation, cytokines, and culture conditions
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Natalia Lehman and Michal Zarobkiewicz |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science Center of Poland |
No. 2019/35/N/NZ6/02973 |
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| Corresponding Author |
Michal Zarobkiewicz, Associate Professor, MD, PhD, Department of Clinical Immunology, Medical University of Lublin, Chodzki 4A, Lublin 20-093, Lubelskie, Poland. michal.zarobkiewicz@umlub.pl |
| Key Words |
Vδ2; γδT; Expansion; Immunotherapy; Zoledronate; N-aminobisphosphonates; Mevalonate pathway |
| Core Tip |
Vδ2 γδT cells hold promise for cancer immunotherapy due to their major histocompatibility complex-independent recognition of phosphoantigens and relative ease of their large scale GMP-compliant expansion in vitro. This mini-review outlines current strategies to optimize Vδ2 T cell expansion, highlighting the roles of stimuli, cytokine combinations, and culture conditions. Emerging insights on direct phosphoantigen stimulation and Toll-like receptor-based co-stimulation are also discussed, offering new avenues to enhance γδT cell yield and functionality for therapeutic use. |
| Publish Date |
2025-10-24 06:10 |
| Citation |
<p>Lehman N, Zarobkiewicz M. Expansion strategies for Vδ2 γδT cells in cancer immunotherapy: Activation, cytokines, and culture conditions. <i>World J Clin Oncol</i> 2025; 16(10): 110466</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i10/110466.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i10.110466 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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