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12/5/2025 11:28:04 AM | Browse: 14 | Download: 37
Publication Name World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID 110472
Country Pakistan
Received
2025-06-09 10:20
Peer-Review Started
2025-06-09 10:21
First Decision by Editorial Office Director
2025-07-03 10:42
Return for Revision
2025-07-03 10:42
Revised
2025-07-24 18:10
Publication Fee Transferred
Second Decision by Editor
2025-10-30 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-10-30 10:12
Articles in Press
2025-10-30 10:12
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-11-24 01:21
Publish the Manuscript Online
2025-12-05 11:28
ISSN 2150-5349 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, General & Internal
Manuscript Type Minireviews
Article Title Emerging role of Janus kinase inhibitors in ulcerative colitis management
Manuscript Source Invited Manuscript
All Author List Muhammad Umar Ahsan, Syeda Laiba Sajid, Rahul Balach, Muhammad Daniyal, Noor Ul Ain and Muhammad Mudasir
ORCID
Author(s) ORCID Number
Muhammad Umar Ahsan http://orcid.org/0009-0008-0627-2521
Syeda Laiba Sajid http://orcid.org/0009-0000-0942-756X
Rahul Balach http://orcid.org/0009-0003-1593-0622
Noor Ul Ain http://orcid.org/0009-0004-1345-6821
Funding Agency and Grant Number
Corresponding Author Muhammad Umar Ahsan, Researcher, Department of medicine, D.G. Khan Medical College, D.G.Khan Medical College, Dera Ghazi Khan, Punjab, Pakistan., Dera Ghazi Khan 32200, Punjab, Pakistan. umarahsan219@gmail.com
Key Words Ulcerative colitis; Janus Kinase inhibitors; Tofacitinib; Upadacitinib; Small molecules; Inflammatory bowel disease; Targeted therapy
Core Tip Ulcerative colitis (UC) is a difficult condition that often doesn’t respond well to standard treatments. This review looks at the growing role of Janus kinase (JAK) inhibitors, a type of oral medication that targets specific pathways involved in inflammation. While older drugs like tofacitinib showed promise, they raised some safety concerns. Newer options, such as upadacitinib and filgotinib, appear to offer better safety alongside strong clinical results. Overall, this review highlights how these treatments could help people with moderate-to-severe UC who need more effective and reliable options to manage their condition.
Publish Date 2025-12-05 11:28
Citation

Ahsan MU, Sajid SL, Balach R, Daniyal M, Ain NU, Mudasir M. Emerging role of Janus kinase inhibitors in ulcerative colitis management. World J Gastrointest Pharmacol Ther 2025; 16(4): 110472

URL https://www.wjgnet.com/2150-5349/full/v16/i4/110472.htm
DOI https://dx.doi.org/10.4292/wjgpt.v16.i4.110472
Full Article (PDF) WJGPT-16-110472-with-cover.pdf
Manuscript File 110472_Auto_Edited_011329.docx
Answering Reviewers 110472-answering-reviewers.pdf
Audio Core Tip 110472-audio.mp3
Conflict-of-Interest Disclosure Form 110472-conflict-of-interest-statement.pdf
Copyright License Agreement 110472-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 110472-non-native-speakers.pdf
Peer-review Report 110472-peer-reviews.pdf
Scientific Misconduct Check 110472-scientific-misconduct-check.png
Scientific Editor Work List 110472-scientific-editor-work-list.pdf
CrossCheck Report 110472-crosscheck-report.pdf