| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Review |
| Article Title |
Urinary biomarkers of diabetic kidney disease
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Guido Gembillo, Luca Soraci, Rossella Messina, Lorenzo Lo Cicero, Giuseppe Spadaro, Felicia Cuzzola, Michela Calderone, Maria Federica Ricca, Simona Di Piazza, Flavia Sudano, Luigi Peritore and Domenico Santoro |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Guido Gembillo, Consultant, MD, PhD, Unit of Nephrology and Dialysis, AOU “G. Martino”, University of Messina, Via Consolare Valeria n 1, Messina 98125, Sicilia, Italy. ggembillo@gmail.com |
| Key Words |
Diabetic nephropathy; Diabetes; Renal disease; End-stage renal disease; Tubular injury; Microalbuminuria; Cystatin C; MicroRNA; Metabolomics; Proteomics |
| Core Tip |
Diabetic kidney disease is a major complication of diabetes and a leading cause of chronic kidney disease. Traditional markers such as albuminuria and estimated glomerular filtration rate often detect damage at a late stage, limiting early intervention. Emerging urinary biomarkers including kidney injury molecule 1, neutrophil gelatinase associated lipocalin, monocyte chemoattractant protein 1, and urinary microRNAs offer earlier and more specific detection of tubular injury, inflammation, and oxidative stress. These biomarkers enhance risk assessment, disease monitoring, and evaluation of treatment response. Incorporating them into clinical practice could enable earlier diagnosis, personalized therapy, and improved outcomes in diabetic kidney disease management. |
| Publish Date |
2026-01-14 08:09 |
| Citation |
Gembillo G, Soraci L, Messina R, Lo Cicero L, Spadaro G, Cuzzola F, Calderone M, Ricca MF, Di Piazza S, Sudano F, Peritore L, Santoro D. Urinary biomarkers of diabetic kidney disease. World J Diabetes 2026; 17(1): 110502 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i1/110502.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i1.110502 |
