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Articles Published Processes
2/4/2026 6:28:25 AM | Browse: 1 | Download: 0
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Received |
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2025-06-09 10:35 |
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Peer-Review Started |
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2025-06-09 10:36 |
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First Decision by Editorial Office Director |
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2025-07-22 09:44 |
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Return for Revision |
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2025-07-22 09:44 |
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Revised |
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2025-07-28 14:05 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-24 02:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-24 08:44 |
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Articles in Press |
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2025-11-24 08:44 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-21 07:28 |
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Publish the Manuscript Online |
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2026-02-04 06:28 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Minireviews |
| Article Title |
Phosphatidylinositol-3-kinase/protein kinase B signaling dysregulation in steroid-induced osteonecrosis of the femoral head: A minireview of therapeutic implications
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ya-Nan Wang, Jun-Xia Jiang, Cheng-Xiang Pang, Lei Sun, Ran Sun, Feng-Ming Wang and Hong-Jiang Jiang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hong-Jiang Jiang, MD, President, Professor, Department of Orthopedics, Shandong Wendeng Orthopedic Hospital, No.1 Fengshan Road, Wendeng District, Weihai 264400, Shandong Province, China. wdzggys@163.com |
| Key Words |
Femoral head necrosis; Phosphatidylinositol-3-kinase/protein kinase B signaling pathway; Glucocorticoids; Angiogenesis; Apoptosis; Molecular targeted therapy; Cell differentiation |
| Core Tip |
Steroid-induced osteonecrosis of the femoral head (SIONFH) is a debilitating disorder associated with prolonged glucocorticoid therapy. The phosphatidylinositol-3-kinase/protein kinase B signaling pathway plays a critical role in regulating the survival, differentiation, and angiogenesis of bone cells. This mini-review highlighted how glucocorticoid-induced dysregulation of the phosphatidylinositol-3-kinase/protein kinase B pathway in osteoblasts, osteoclasts, mesenchymal stem cells, and endothelial cells contributed to the pathogenesis of SIONFH. We reviewed emerging therapeutic strategies targeting this pathway and provided new insights into potential interventions for early-stage SIONFH. |
| Publish Date |
2026-02-04 06:28 |
| Citation |
Wang YN, Jiang JX, Pang CX, Sun L, Sun R, Wang FM, Jiang HJ. Phosphatidylinositol-3-kinase/protein kinase B signaling dysregulation in steroid-induced osteonecrosis of the femoral head: A minireview of therapeutic implications. World J Orthop 2026; 17(2): 110517 |
| URL |
https://www.wjgnet.com/2218-5836/full/v17/i2/110517.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v17.i2.110517 |
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