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Articles Published Processes
9/15/2025 8:38:03 AM | Browse: 8 | Download: 0
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Received |
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2025-06-10 15:15 |
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Peer-Review Started |
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2025-06-10 15:15 |
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To Make the First Decision |
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Return for Revision |
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2025-07-01 03:02 |
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Revised |
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2025-07-06 12:46 |
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Second Decision |
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2025-08-06 02:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-06 08:38 |
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Articles in Press |
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2025-08-06 08:38 |
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Publication Fee Transferred |
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2025-07-13 04:40 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-02 00:48 |
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Publish the Manuscript Online |
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2025-09-15 08:38 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Transcription factor 3 enhances hepatocellular carcinoma metastasis by upregulating matrix metalloproteinase-11
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong-Peng Tian, Tian-Hao Wu, Guang-Jun Zhang and Sheng-Jie Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Sichuan Clinical Key Specialty |
No. 2017JQ0039 |
| Sichuan Clinical Key Specialty |
No. 2017KZ0028 |
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| Corresponding Author |
Sheng-Jie Li, Professor, Department of Colorectal Surgery, University of Health and Rehabilitation Sciences, Qingdao Municipal Hospital, No. 5 Donghai Zhong Road, Qingdao 266000, Shandong Province, China. lishengjieq@163.com |
| Key Words |
Hepatocellular carcinoma; Transcription factor 3; Matrix metalloproteinase-11; Migration; Invasion |
| Core Tip |
Elevated transcription factor 3 (TCF3) levels were observed in hepatocellular carcinoma (HCC) samples and were associated with unfavorable outcomes. Additionally, overexpression of TCF3 facilitated the invasion and migration of HCC cells, while knocking down TCF3 suppressed their growth. In addition, TCF3 interacts with the promoter region of matrix metalloproteinase-11 (MMP11), facilitating the transcriptional activation of MMP11 mRNA, which consequently enhances the expression of MMP11. MMP11 knockdown repressed TCF3-associated HCC cell migration and invasion, while its overexpression attenuated the TCF3 knockdown-mediated repression of HCC growth. In human-derived HCC samples, TCF3 was positively correlated with MMP11 expression levels. |
| Publish Date |
2025-09-15 08:38 |
| Citation |
<p>Tian HP, Wu TH, Zhang GJ, Li SJ. Transcription factor 3 enhances hepatocellular carcinoma metastasis by upregulating matrix metalloproteinase-11. <i>World J Gastrointest Oncol</i> 2025; 17(9): 110527</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i9/110527.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i9.110527 |
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