Publication Name	World Journal of Psychiatry
Manuscript ID	110581
Country	China

Received	2025-06-11 03:47
Peer-Review Started	2025-06-11 03:47
To Make the First Decision
Return for Revision	2025-07-21 07:52
Revised	2025-07-31 10:29
Second Decision	2025-08-20 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-20 08:16
Articles in Press	2025-08-20 08:16
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-08-24 21:54
Typeset the Manuscript	2025-10-21 09:45
Publish the Manuscript Online	2025-11-04 02:41

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Psychiatry
Manuscript Type	Editorial
Article Title	DNA methylation as a new frontier in treating fear-related disorders: A need for careful evaluation
Manuscript Source	Invited Manuscript
All Author List	Xiao-Ling Huang, De-Fang Chen, Ying Wang, Yi-Ning Zhang, Ntim Michael, Yu-Song Ge and Bin Wang
ORCID	Author(s) ORCID Number Yu-Song Ge http://orcid.org/0000-0001-7889-1462 Bin Wang http://orcid.org/0000-0002-5509-6375
Funding Agency and Grant Number	Funding Agency Grant Number General Program of the Joint Fund Project Under the Liaoning Provincial Science and Technology Plan 2024-MSLH-104 Research Project Plan of the Qingpu Branch of Zhongshan Hospital QYT2023-02 Research Topic of the Shanghai Qingpu District Health Commission QWJ2024-10
Corresponding Author	Bin Wang, Liaoning Provincial Key Laboratory of Cerebral Diseases, College of Basic Medical Sciences, National-Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases, Dalian Medical University, Liaoning Provincial Key Laboratory of Cerebral Diseases, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liasonaing, China. Electronic address: wb101900@126.com, Dalian 116000, Liaoning Province, China. wb101900@126.com
Key Words	DNA methylation; Fear extinction; Exposure therapy; Fear-related disorders; Neuronal plasticity; Epigenetic regulation
Core Tip	DNA methylation shows therapeutic potential in fear-related disorders such as post-traumatic stress disorder by modulating fear memory extinction. However, concerns regarding its limited specificity, uncertain timing of intervention, and potential systemic side effects warrant cautious interpretation. Future research should focus on enhancing spatial precision, optimizing temporal control, and conducting individualized assessments to improve therapeutic accuracy. Ethical oversight and the integration of multi-faceted strategies will be essential for the safe and effective clinical application of DNA methylation-based interventions.
Publish Date	2025-11-04 02:41
Citation	<p>Huang XL, Chen DF, Wang Y, Zhang YN, Michael N, Ge YS, Wang B. DNA methylation as a new frontier in treating fear-related disorders: A need for careful evaluation. <i>World J Psychiatry</i> 2025; 15(11): 110581</p>
URL	https://www.wjgnet.com/2220-3206/full/v15/i11/110581.htm
DOI	https://dx.doi.org/10.5498/wjp.v15.i11.110581

Full Article (PDF)	WJP-15-110581-with-cover.pdf
Manuscript File	110581_Auto_Edited_034356.docx
Answering Reviewers	110581-answering-reviewers.pdf
Audio Core Tip	110581-audio.mp3
Conflict-of-Interest Disclosure Form	110581-conflict-of-interest-statement.pdf
Copyright License Agreement	110581-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	110581-non-native-speakers.pdf
Supplementary Material	110581-supplementary-material.pdf
Peer-review Report	110581-peer-reviews.pdf
Scientific Misconduct Check	110581-scientific-misconduct-check.png
Scientific Editor Work List	110581-scientific-editor-work-list.pdf
CrossCheck Report	110581-crosscheck-report.pdf