BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
10/29/2014 7:34:00 PM | Browse: 1181 | Download: 1704
 |
Received |
|
2014-05-02 13:21 |
|
Peer-Review Started |
|
2014-05-02 13:34 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2014-06-18 16:34 |
|
Revised |
|
2014-06-29 19:55 |
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2014-07-16 12:59 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2014-07-16 13:12 |
|
Articles in Press |
|
2014-07-16 17:57 |
|
Edit the Manuscript by Language Editor |
|
2014-07-23 20:57 |
|
Typeset the Manuscript |
|
2014-10-17 11:40 |
|
Publish the Manuscript Online |
|
2014-10-29 19:34 |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Autobiography |
| Article Title |
Effect of oridonin-mediated hallmark changes on inflammatory pathways in human pancreatic cancer (BxPC-3) cells
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ru-Yi Chen, Bin Xu, Su-Feng Chen, Si-Si Chen, Ting Zhang, Jun Ren and Jian Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Qianjiang Talent Project of Zhejiang Province |
2013R10072 |
| Natural Science Foundation of Zhejiang Province |
LY14H160037 |
| Natural Science Foundation of Zhejiang Province |
LY12H16007 |
|
| Corresponding Author |
Jian Xu, PhD, Associate Professor, The College of Life Science, Zhejiang Chinese Medical University, Bin Wen Road, Bin Jiang District, Hangzhou 310053, Zhejiang Province, China. xujian832002@163.com |
| Key Words |
Pancreatic cancer; Hallmarks; Oridonin; Inflammatory pathways; Nuclear transcription factors |
| Core Tip |
Pancreatic cancer is a common cancer of the digestive system and is a leading cause of morbidity and mortality worldwide. In this report, we demonstrate that oridonin is able to inhibit the growth of human pancreatic cancer (BxPC-3) cells and change the expression of cancer hallmark-related proteins. Inflammatory factors were decreased in BxPC-3 cells treated with oridonin, and oridonin also regulated nuclear transcription factor pathways. We propose that oridonin can reduce growth, metastasis, and angiogenesis in BxPC-3 cells by regulating the nuclear transcription factor-mediated expression of related inflammatory factors. |
| Publish Date |
2014-10-29 19:34 |
| Citation |
Chen RY, Xu B, Chen SF, Chen SS, Zhang T, Ren J, Xu J. Effect of oridonin-mediated hallmark changes on inflammatory pathways in human pancreatic cancer (BxPC-3) cells. World J Gastroenterol 2014; 20(40): 14895-14903 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i40/14895.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i40.14895 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
