Publication Name	World Journal of Gastroenterology
Manuscript ID	11059
Country	China

Received	2014-05-02 13:21
Peer-Review Started	2014-05-02 13:34
To Make the First Decision	2014-06-10 13:21
Return for Revision	2014-06-18 16:34
Revised	2014-06-29 19:55
Second Decision	2014-07-16 12:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-07-16 13:12
Articles in Press	2014-07-16 17:57
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-23 20:57
Typeset the Manuscript	2014-10-17 11:40
Publish the Manuscript Online	2014-10-29 19:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Autobiography
Article Title	Effect of oridonin-mediated hallmark changes on inflammatory pathways in human pancreatic cancer (BxPC-3) cells
Manuscript Source	Unsolicited Manuscript
All Author List	Ru-Yi Chen, Bin Xu, Su-Feng Chen, Si-Si Chen, Ting Zhang, Jun Ren and Jian Xu
Funding Agency and Grant Number	Funding Agency Grant Number Qianjiang Talent Project of Zhejiang Province 2013R10072 Natural Science Foundation of Zhejiang Province LY14H160037 Natural Science Foundation of Zhejiang Province LY12H16007
Corresponding Author	Jian Xu, PhD, Associate Professor, The College of Life Science, Zhejiang Chinese Medical University, Bin Wen Road, Bin Jiang District, Hangzhou 310053, Zhejiang Province, China. xujian832002@163.com
Key Words	Pancreatic cancer; Hallmarks; Oridonin; Inflammatory pathways; Nuclear transcription factors
Core Tip	Pancreatic cancer is a common cancer of the digestive system and is a leading cause of morbidity and mortality worldwide. In this report, we demonstrate that oridonin is able to inhibit the growth of human pancreatic cancer (BxPC-3) cells and change the expression of cancer hallmark-related proteins. Inflammatory factors were decreased in BxPC-3 cells treated with oridonin, and oridonin also regulated nuclear transcription factor pathways. We propose that oridonin can reduce growth, metastasis, and angiogenesis in BxPC-3 cells by regulating the nuclear transcription factor-mediated expression of related inflammatory factors.
Publish Date	2014-10-29 19:34
Citation	Chen RY, Xu B, Chen SF, Chen SS, Zhang T, Ren J, Xu J. Effect of oridonin-mediated hallmark changes on inflammatory pathways in human pancreatic cancer (BxPC-3) cells. World J Gastroenterol 2014; 20(40): 14895-14903
URL	http://www.wjgnet.com/1007-9327/full/v20/i40/14895.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i40.14895

Full Article (PDF)	WJG-20-14895.pdf
Full Article (Word)	WJG-20-14895.doc
Manuscript File	11059-Review.doc
Answering Reviewers	11059-Answering reviewers.pdf
Copyright License Agreement	11059-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11059-Language certificate.pdf
Peer-review Report	11059-Peer reviews.pdf
Scientific Misconduct Check	11059-CrossCheck.jpg
Scientific Editor Work List	11059-Scientific editor work list.pdf