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Articles Published Processes
12/25/2025 8:27:20 AM | Browse: 0 | Download: 0
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Received |
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2025-08-01 07:50 |
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Peer-Review Started |
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2025-08-01 07:50 |
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First Decision by Editorial Office Director |
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2025-08-20 06:59 |
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Return for Revision |
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2025-08-20 06:59 |
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Revised |
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2025-09-12 05:28 |
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Publication Fee Transferred |
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2025-09-15 11:02 |
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Second Decision by Editor |
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2025-10-17 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-17 06:19 |
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Articles in Press |
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2025-10-17 06:19 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-15 02:48 |
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Publish the Manuscript Online |
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2025-12-25 08:27 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Visual screening and efficacy evaluation of high-performance fluorescent probe DAF-FM in esophagitis cancer transformation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wan-Hua Chen, Cheng-Feng Cai, Bing-Zhong Gao, Wen-Shan Hong, Ying-Zhi Xu and Wen-Jie Cai |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Fujian Province |
No. 2023J011787 |
| Quanzhou Science and Technology Program Project |
No. 2025QZC02DW |
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| Corresponding Author |
Wen-Jie Cai, Chief Physician, Department of Radiation Oncology, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 248-252 East Street, Quanzhou 362002, Fujian Province, China. caiwj2001@126.com |
| Key Words |
DAF-FM; Fluorescent probe; Esophageal cancer transformation; Nitric oxide; Visual screening; Efficacy evaluation; Lysosomal targeting |
| Core Tip |
This study systematically evaluated the high-performance fluorescent probe DAF-FM for visual screening and efficacy assessment of esophagitis-to-cancer transformation. DAF-FM exhibited concentration-dependent and time-dependent fluorescence responses to nitric oxide (NO), targeted lysosomes specifically (Pearson coefficient = 0.82 ± 0.03), and had low cytotoxicity (82.3% ± 4.1% cell viability at 50 μM). In Sprague-Dawley rat esophagitis cancer models, DAF-FM monitored NO changes dynamically, with results positively correlated to tumor volume (R² = 0.87) post 5-fluorouracil/radiotherapy. Clinically, it outperformed endoscopic biopsy (sensitivity: 92.5% vs 78.3%) and shortened detection time (30 minutes vs 48 hours). Mechanistically, NO regulates carcinogenesis via the nuclear factor-kappa B pathway, clarifying DAF-FM’s molecular logic in reflecting transformation stages. |
| Publish Date |
2025-12-25 08:27 |
| Citation |
Chen WH, Cai CF, Gao BZ, Hong WS, Xu YZ, Cai WJ. Visual screening and efficacy evaluation of high-performance fluorescent probe DAF-FM in esophagitis cancer transformation. World J Gastrointest Surg 2025; 17(12): 110617 |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i12/110617.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i12.110617 |
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