| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Anthropology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
In vitro and clinical evaluation of platelet-rich plasma combined with angioplasty in diabetic foot treatment
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chen Huang, He-Zhu Liu, Jia-Bin Liang, Wei Zhao, Yan-Sheng Wang, Li-Fen Ruan, Wei-Zhao Zhuang, Yong-Sheng Li, Qian Wang and Yu-Kuan Tang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medical Science and Technology Foundation of Guangdong Province |
A2024625 |
| Guangzhou Municipal Science and Technology Program Key Projects |
202103000002 |
| Panyu Science and Technology Planning Project |
2023-Z04-019 |
|
| Corresponding Author |
Yu-Kuan Tang, Director, MD, Department of Minimally Invasive Interventional Radiology, The Affiliated Panyu Central Hospital of Guangzhou Medical University, No. 8 East Fuyu Road Qiaonan Street, Panyu District, Guangzhou 511400, Guangdong Province, China. tyk20126@126.com |
| Key Words |
Angiogenesis; Diabetic foot; Endovascular angioplasty; Platelet-rich plasma; Wound healing |
| Core Tip |
This study investigated the effect of platelet-rich plasma (PRP) combined with endovascular angioplasty on diabetic foot ulcers (DFUs). The findings revealed that PRP improved the proliferation and migration of human umbilical vein endothelial cells, human dermal fibroblasts, and human immortalized keratinocytes. It also activated p38, Ak strain transforming and Extracellular Regulated protein Kinases1/2, and upregulated vascular endothelial growth factor receptor 2 to promote angiogenesis. PRP combined with endovascular angioplasty improved microcirculation, especially in the lower limb ischemic area, and promoted tissue repair in DFU conditions. The combination of 6% activated PRP and endovascular angioplasty demonstrated a notable effect in improving DFU conditions, providing a novel treatment option for patients with DFUs. |
| Publish Date |
2025-10-15 09:03 |
| Citation |
<p>Huang C, Liu HZ, Liang JB, Zhao W, Wang YS, Ruan LF, Zhuang WZ, Li YS, Wang Q, Tang YK. In vitro and clinical evaluation of platelet-rich plasma combined with angioplasty in diabetic foot treatment. <i>World J Diabetes</i> 2025; 16(10): 110631</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i10/110631.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i10.110631 |
