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11/27/2025 7:53:58 AM | Browse: 17 | Download: 59
Publication Name World Journal of Hepatology
Manuscript ID 110638
Country Egypt
Received
2025-06-11 10:13
Peer-Review Started
2025-06-11 10:13
First Decision by Editorial Office Director
2025-07-25 07:04
Return for Revision
2025-07-25 07:04
Revised
2025-07-27 17:23
Publication Fee Transferred
Second Decision by Editor
2025-10-23 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-10-23 10:42
Articles in Press
2025-10-23 10:42
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-11-18 00:33
Publish the Manuscript Online
2025-11-27 07:53
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Direct-acting antiviral therapy reduces variceal rebleeding and improves liver function in hepatitis C virus-related cirrhosis: A multicenter retrospective cohort study
Manuscript Source Invited Manuscript
All Author List Raafat SA Abdel Hafez, Atteyat A Semeya, Rasha Elgamal and Amira AA Othman
ORCID
Author(s) ORCID Number
Amira AA Othman http://orcid.org/0000-0002-8191-0035
Funding Agency and Grant Number
Corresponding Author Amira AA Othman, PhD, Department of Internal Medicine, Faculty of Medicine, Suez University, Cairo-Suez Road, Suez 43511, Egypt. amira.othman@med.suezuni.edu.eg
Key Words Direct-acting antivirals; Variceal rebleeding; Portal hypertension; Sustained virologic response; Genotype 4; Egypt
Core Tip Direct-acting antivirals (DAAs) are known to improve liver function in hepatitis C-related cirrhosis. However, their effect on portal hypertension and variceal rebleeding in genotype 4 patients remains underexplored. This multicenter retrospective study in Egypt reveals that DAA therapy is associated with a significantly lower risk of rebleeding and hepatic decompensation, supporting their role in secondary prevention post-variceal hemorrhage.
Publish Date 2025-11-27 07:53
Citation

Abdel Hafez RS, Semeya AA, Elgamal R, Othman AA. Direct-acting antiviral therapy reduces variceal rebleeding and improves liver function in hepatitis C virus-related cirrhosis: A multicenter retrospective cohort study. World J Hepatol 2025; 17(11): 110638

URL https://www.wjgnet.com/1948-5182/full/v17/i11/110638.htm
DOI https://dx.doi.org/10.4254/wjh.v17.i11.110638
Full Article (PDF) WJH-17-110638-with-cover.pdf
STROBE Statement 110638-STROBE-statement.pdf
Manuscript File 110638_Auto_Edited_111242.docx
Answering Reviewers 110638-answering-reviewers.pdf
Audio Core Tip 110638-audio.mp3
Biostatistics Review Certificate 110638-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 110638-conflict-of-interest-statement.pdf
Copyright License Agreement 110638-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 110638-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 110638-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 110638-non-native-speakers.pdf
Peer-review Report 110638-peer-reviews.pdf
Scientific Misconduct Check 110638-scientific-misconduct-check.png
Scientific Editor Work List 110638-scientific-editor-work-list.pdf
CrossCheck Report 110638-crosscheck-report.pdf