| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Real-world effectiveness and safety of teduglutide in adult and pediatric patients with short bowel syndrome in Argentina
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Héctor Solar Muñiz, Adriana Fernández, Verónica Busoni, María Inés Martínez, Carolina Rumbo, Silvia De Barrio, Carola Saure, Martín Balacco, Martín Gonzalo Buncuga, Corina Dlugoszweski, Alejandra Manzur, Lorena Rudi, María Dolores Matoso, Sandra Cosentino, Federico Ussher, Fernando Manzur, Julia Demarchi, Elisa Malaver, Laura Brion and Laura Ungar |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Takeda Argentina SA |
No. TAK-633-4003 |
|
| Corresponding Author |
Laura Ungar, MD, Department of Medical Affairs, Takeda Argentina SA, Avenida Del Libertador 7208, Buenos Aires C1429, Argentina. laura.ungar@takeda.com |
| Key Words |
Short bowel syndrome; Intestinal failure; Parenteral nutrition; Parenteral support; Weaning; teduglutide; Real-world |
| Core Tip |
This multicenter real-world evidence study demonstrates the effectiveness and safety of teduglutide in adult and pediatric patients with short bowel syndrome-IF in the Latin American population. The results showed that teduglutide induced significant reductions in parenteral support (PS) in both adult and pediatric populations, consistent with pivotal studies, with a low incidence of mild to moderate adverse events. The findings highlight the importance of early identification of eligible patients for teduglutide (patients with reduced baseline PS volume dependence and/or favorable bowel anatomy), which may increase the likelihood of achieving PS independence. This approach could potentially reduce the morbidity associated with intestinal failure, ultimately improving long-term patient outcomes in Latin America. |
| Publish Date |
2025-12-05 11:28 |
| Citation |
Solar Muñiz H, Fernández A, Busoni V, Martínez MI, Rumbo C, De Barrio S, Saure C, Balacco M, Buncuga MG, Dlugoszweski C, Manzur A, Rudi L, Matoso MD, Cosentino S, Ussher F, Manzur F, Demarchi J, Malaver E, Brion L, Ungar L. Real-world effectiveness and safety of teduglutide in adult and pediatric patients with short bowel syndrome in Argentina. World J Gastrointest Pharmacol Ther 2025; 16(4): 110642 |
| URL |
https://www.wjgnet.com/2150-5349/full/v16/i4/110642.htm |
| DOI |
https://dx.doi.org/10.4292/wjgpt.v16.i4.110642 |
