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Articles Published Processes
9/25/2025 11:24:02 AM | Browse: 75 | Download: 86
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Received |
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2025-06-12 09:12 |
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Peer-Review Started |
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2025-06-12 09:12 |
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First Decision by Editorial Office Director |
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2025-06-17 10:53 |
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Return for Revision |
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2025-06-17 12:33 |
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Revised |
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2025-06-25 15:05 |
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Publication Fee Transferred |
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2025-07-02 10:50 |
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Second Decision by Editor |
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2025-08-15 02:54 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-08-15 08:27 |
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Articles in Press |
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2025-08-15 08:27 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-17 06:45 |
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Publish the Manuscript Online |
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2025-09-25 11:24 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Prognostic value of dynamic changes in C-reactive protein to albumin ratio in patients with acute-on-chronic liver failure
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zong-Yi Zhu and Li-Juan Yan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Li-Juan Yan, Chief Physician, Director, Department of Gastroenterology, Handan Central hospital, No. 59 Congtai North Road, Congtai District, Handan 056000, Hebei Province, China. ylj456789@126.com |
| Key Words |
Acute-on-chronic liver failure; C-reactive protein to albumin ratio; Inflammation; Prognosis; Chinese Group on Study of Severe Hepatitis B criteria; Mortality |
| Core Tip |
This study demonstrates that dynamic changes in C-reactive protein to albumin ratio (CAR) during the first week after admission provide superior prognostic value compared to baseline measurements in patients with acute-on-chronic liver failure (ACLF). The optimal predictive timepoint was day 7 change from baseline (ΔCAR-7). A novel Chinese Group on Study of Severe Hepatitis B (COSSH)-CAR prognostic model, incorporating ΔCAR-7, baseline Model for End-Stage Liver Disease-Sodium (MELD-Na) score, and hepatic encephalopathy grade, significantly outperformed established scoring systems including Child-Pugh, MELD-Na, and COSSH-ACLF scores. This dynamic biomarker approach offers enhanced risk stratification and may improve clinical decision-making in ACLF management. |
| Publish Date |
2025-09-25 11:24 |
| Citation |
Zhu ZY, Yan LJ. Prognostic value of dynamic changes in C-reactive protein to albumin ratio in patients with acute-on-chronic liver failure. World J Hepatol 2025; 17(9): 110652 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i9/110652.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i9.110652 |
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