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Articles Published Processes
9/24/2025 3:48:39 AM | Browse: 17 | Download: 32
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Received |
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2025-06-13 09:48 |
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Peer-Review Started |
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2025-06-13 09:49 |
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To Make the First Decision |
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Return for Revision |
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2025-07-08 06:39 |
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Revised |
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2025-07-22 06:35 |
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Second Decision |
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2025-08-28 01:07 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-04 10:12 |
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Articles in Press |
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2025-09-04 10:12 |
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Publication Fee Transferred |
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2025-07-29 03:26 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-11 07:54 |
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Publish the Manuscript Online |
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2025-09-24 03:48 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Emergency Medicine |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Combined mesenchymal and neural stem cell therapy enhances neurological recovery in cerebral infarction
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ting Yang, Hui Yu, Dong Han and Zheng Xie |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hui Yu, Department of Emergency, Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Binhu District, Wuxi 214000, Jiangsu Province, China. yuhuiyh56@163.com |
| Key Words |
Acute cerebral infarction; Neural stem cells; Mesenchymal stem cells; Vascular endothelial growth factor; Basic fibroblast growth factor; Neurological function |
| Core Tip |
Combination therapy with neural stem cell (NSC) and mesenchymal stem cell (MSC) promotes neurological recovery in patients with acute cerebral infarction (ACI) by modulating vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) expression, thereby enhancing cerebral perfusion, daily living capacity, and neurological function scores. This study validated the efficacy and safety of NSC/MSC stem cell combination therapy, and systematically elucidated the mechanistic roles of VEGF and bFGF in the NSC-MSC-mediated treatment of ACI. These findings further demonstrate the central regulatory roles of VEGF and bFGF in angiogenesis and neural repair, thereby advancing the application of precision medicine in ACI treatment, and providing a robust theoretical foundation and future directions for clinical translation. |
| Publish Date |
2025-09-24 03:48 |
| Citation |
<p>Yang T, Yu H, Han D, Xie Z. Combined mesenchymal and neural stem cell therapy enhances neurological recovery in cerebral infarction. <i>World J Stem Cells</i> 2025; 17(9): 110663</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i9/110663.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i9.110663 |
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