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Articles Published Processes
9/25/2025 11:24:01 AM | Browse: 66 | Download: 49
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Received |
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2025-06-12 03:18 |
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Peer-Review Started |
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2025-06-12 03:18 |
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To Make the First Decision |
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Return for Revision |
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2025-06-18 07:11 |
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Revised |
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2025-06-24 02:26 |
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Second Decision |
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2025-08-11 02:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-11 09:52 |
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Articles in Press |
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2025-08-11 09:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-12 03:03 |
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Publish the Manuscript Online |
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2025-09-25 11:24 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Rapamycin nanoparticles suppress autoreactive lymphocytes and reduce anti-mitochondrial antibodies in primary biliary cholangitis: Mechanisms and implications
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Payal Bhatnagar and Nabil Eid |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Nabil Eid, Associate Professor, MD, PhD, Department of Human Biology, Division of Anatomy, School of Medicine, IMU University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my |
| Key Words |
Autoimmune disease; Lymphocytes; Autophagy; Apoptosis; Nanoparticles encapsulating rapamycin; Rapamycin nanoparticles; Primary biliary cholangitis |
| Core Tip |
Primary biliary cholangitis (PBC) is an autoimmune disease with limited therapeutic options. A recent study using a mouse model of PBC found that nanoparticles encapsulating rapamycin treatment reduced the levels of autoreactive T cells and B cells in the liver and spleen, improved liver inflammation and enzyme levels, and was associated with a concomitant decrease in anti-mitochondrial antibody levels. These findings indicate that nanoparticles encapsulating rapamycin may improve liver pathology in the PBC mouse model through mammalian target of rapamycin inhibition and potential autophagy restoration, suggesting it could represent a novel therapeutic option for this chronic disease. |
| Publish Date |
2025-09-25 11:24 |
| Citation |
<p>Bhatnagar P, Eid N. Rapamycin nanoparticles suppress autoreactive lymphocytes and reduce anti-mitochondrial antibodies in primary biliary cholangitis: Mechanisms and implications. <i>World J Hepatol</i> 2025; 17(9): 110674</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i9/110674.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i9.110674 |
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