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Articles Published Processes
9/19/2025 7:57:23 AM | Browse: 310 | Download: 38
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Received |
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2025-06-13 08:21 |
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Peer-Review Started |
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2025-06-13 08:22 |
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To Make the First Decision |
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Return for Revision |
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2025-06-30 07:24 |
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Revised |
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2025-07-21 12:43 |
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Second Decision |
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2025-09-01 02:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-01 05:12 |
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Articles in Press |
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2025-09-01 05:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-11 06:48 |
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Publish the Manuscript Online |
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2025-09-19 07:57 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Patient-derived organoids in hepatobiliary pancreatic cancer research: Their uses and limitations
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sam Jacobs, William Butterworth and Ewen A Griffiths |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ewen A Griffiths, Department of Upper Gastrointestinal Surgery, University Hospitals Birmingham NHS Foundation Trust, Mindelsohn Way, Birmingham B15 2GW, United Kingdom. ewen.griffiths@uhb.nhs.uk |
| Key Words |
Patient-derived organoids; Organ-on-a-chip; Sensitivity testing; Co-cultures; Tumour microenvironment |
| Core Tip |
The development of organoid models is becoming an exciting field in in-vitro drug testing for chemotherapy for aggressive cancers, such as hepatobiliary pancreatic. The most reliable source of organoid establishment is from resected tumour, however liquid biopsies are becoming more common. There is a large amount of heterogeneity in the way organoids are cultured and there are drawbacks of this technique, such as the lack of fidelity in creating the tumour microenvironment and other variables that affect tumour growth. |
| Publish Date |
2025-09-19 07:57 |
| Citation |
<p>Jacobs S, Butterworth W, Griffiths EA. Patient-derived organoids in hepatobiliary pancreatic cancer research: Their uses and limitations. <i>World J Gastroenterol</i> 2025; 31(36): 110684</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i36/110684.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i36.110684 |
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