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Articles Published Processes
9/23/2025 6:49:00 AM | Browse: 132 | Download: 246
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Received |
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2025-06-12 03:25 |
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Peer-Review Started |
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2025-06-12 03:25 |
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First Decision by Editorial Office Director |
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2025-07-08 07:38 |
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Return for Revision |
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2025-07-08 07:38 |
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Revised |
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2025-07-14 20:54 |
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Publication Fee Transferred |
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2025-07-16 15:44 |
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Second Decision by Editor |
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2025-08-20 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-08-20 07:04 |
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Articles in Press |
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2025-08-20 07:04 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-11 00:57 |
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Publish the Manuscript Online |
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2025-09-23 06:49 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Historical rise of cancer and dietary linoleic acid: Mechanisms and therapeutic strategies
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Joseph Mercola |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Joseph Mercola, Researcher, /, Midwestern University, 555 31st Street, Downers Grove, IL 60515, United States. drm@mercola.com |
| Key Words |
Linoleic acid; Cancer mechanisms; Oxidative stress; Mitochondrial dysfunction; Chronic inflammation; Gut microbiota dysbiosis; Dietary seed oils; Short chain fatty acids; Terrain restoration |
| Core Tip |
Industrial seed-oil boom has tripled linoleic acid (LA) intake since 1900, tracking the surge in cancer. This review synthesizes cutting-edge data showing how excess LA seeds oxidative lipid peroxidation, succinate-driven pseudohypoxia, mitochondrial dysfunction, hormonal-inflammatory amplification and gut dysbiosis that together create a “pro-cancer terrain”. It also challenges blanket ketogenic prescriptions, warning that carb exclusion can worsen LA-induced dysbiosis, and outlines a phased “terrain-restoration” plan: Slash dietary LA, reintroduce selective fibers, add odd-chain pentadecanoic acid and metabolic supports to revive mitophagy, microbiota and immune surveillance. The article spotlights urgent research gaps and testable clinical strategies. |
| Publish Date |
2025-09-23 06:49 |
| Citation |
Mercola J. Historical rise of cancer and dietary linoleic acid: Mechanisms and therapeutic strategies. World J Clin Oncol 2025; 16(9): 110686 |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i9/110686.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i9.110686 |
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