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Articles Published Processes
11/4/2025 2:41:49 AM | Browse: 11 | Download: 29
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Received |
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2025-06-13 09:50 |
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Peer-Review Started |
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2025-06-13 09:50 |
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To Make the First Decision |
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Return for Revision |
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2025-07-14 06:44 |
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Revised |
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2025-07-29 02:20 |
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Second Decision |
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2025-08-28 01:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-04 07:13 |
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Articles in Press |
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2025-09-04 07:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-22 02:41 |
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Publish the Manuscript Online |
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2025-11-04 02:41 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Observational Study |
| Article Title |
Cognitive impairment and pain in depression: The mediating role of the kynurenine pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ya-Jun Yun, Qi Zhang, Wen-Xuan Zhao, Ning Fan, Zhi-Ren Wang, Hui-Mei An and Fude Yang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grants from Beijing Municipal Science and Technology Commission |
No. Z191100006619020 |
| Beijing Municipal Administration of Hospitals Incubating Program, 2023 |
No. PX2023070 |
| Beijing Municipal Administration of Hospitals Incubating Program, 2024 |
No. PX2024072 |
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| Corresponding Author |
Fude Yang, Professor, . yangfd2002@163.com |
| Key Words |
Cognition; Pain; Depression; Kynurenine; Tryptophan |
| Core Tip |
This study explores the relationship between the tryptophan-kynurenine (TRP-KYN) pathway and cognitive function in major depressive disorder (MDD) patients with and without painful physical symptoms. By analyzing serum metabolites and clinical assessments, we found that KYN level and TRP/KYN ratio were associated with pain severity but not with cognitive performance. These findings highlight the potential dissociation between pain-related and cognitive mechanisms in MDD and underscore the need for further studies on the biopsychosocial underpinnings of depression-related cognitive dysfunction. |
| Publish Date |
2025-11-04 02:41 |
| Citation |
<p>Yun YJ, Zhang Q, Zhao WX, Fan N, Wang ZR, An HM, Yang F. Cognitive impairment and pain in depression: The mediating role of the kynurenine pathway. <i>World J Psychiatry</i> 2025; 15(11): 110690</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i11/110690.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i11.110690 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
