| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Cytokeratin 18 fragment is associated with steatosis-associated fibrosis estimator score and lipid in patients with steatotic liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tatsuki Ichikawa, Satoshi Miuma, Mio Yamashima, Shinobu Yamamichi, Makiko Koike, Yusuke Nakano, Hiruyuki Yajima, Osamu Miyazaki, Tomonari Ikeda, Takauma Okamura, Naohiro Komatsu, Miruki Yoshino and Hisamitsu Miyaaki |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Tatsuki Ichikawa, MD, Department of Gastroenterology, Nagasaki Harbor Medical Center, 1-7-1 Sakamoto, Nagasaki 850-8555, Japan. ichikawa@nagasaki-u.ac.jp |
| Key Words |
Steatotic liver disease; High-density lipoprotein cholesterol; Triglyceride; Steatosis-associated fibrosis estimator score; Cytokeratin 18 fragment |
| Core Tip |
Serum cytokeratin 18 fragment (CK18F) has been developed as a new non-invasive test for risk assessment of steatotic liver disease (SLD). We included 125 patients who were assessed for SLD and had CK18F measured. Steatosis-associated fibrosis estimator (SAFE) score, liver stiffness (LS), and FibroScan-aspartate aminotransferase (FAST) score were compared with CK18F. CK18F was associated with aspartate aminotransferase, alanine aminotransferase, and triglycerides (TG). FAST and SAFE score were associated with high CK18F (> 260 U/L), but not fibrosis-4 and LS. The risk of high CK18F was higher when high TG and low high-density lipoprotein were combined than when each was present alone. |
| Publish Date |
2025-11-27 07:53 |
| Citation |
Ichikawa T, Miuma S, Yamashima M, Yamamichi S, Koike M, Nakano Y, Yajima H, Miyazaki O, Ikeda T, Okamura T, Komatsu N, Yoshino M, Miyaaki H. Cytokeratin 18 fragment is associated with steatosis-associated fibrosis estimator score and lipid in patients with steatotic liver disease. World J Hepatol 2025; 17(11): 110698 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i11/110698.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i11.110698 |
