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Articles Published Processes
11/14/2025 12:56:14 AM | Browse: 0 | Download: 0
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Received |
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2025-06-16 13:08 |
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Peer-Review Started |
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2025-06-16 13:08 |
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To Make the First Decision |
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Return for Revision |
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2025-07-10 09:13 |
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Revised |
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2025-07-24 01:34 |
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Second Decision |
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2025-09-30 02:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-30 08:53 |
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Articles in Press |
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2025-09-30 08:53 |
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Publication Fee Transferred |
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2025-07-29 09:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-05 00:52 |
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Publish the Manuscript Online |
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2025-11-14 00:56 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Stromal secreted protein acidic and rich in cysteine expression: A potential target for improved prognosis in patients with pancreatic cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hye Yeon Yang, Jae Uk Chong, Mi Jang, Sung Hwan Lee, Ho Kyoung Hwang, Woo Jung Lee and Chang Moo Kang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Faculty Research Grant from Yonsei University College of Medicine |
6-2017-0155 |
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| Corresponding Author |
Chang Moo Kang, MD, PhD, Professor, Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. cmkang@yuhs.ac |
| Key Words |
Pancreatic ductal adenocarcinoma; Secreted protein acidic and rich in cysteine; Tumor microenvironment; Stroma; Survival |
| Core Tip |
This retrospective study investigated the prognostic significance of stromal secreted protein acidic and rich in cysteine (SPARC) expression in resected pancreatic ductal adenocarcinoma. High stromal SPARC expression is associated with inferior recurrence-free and overall survival, particularly in patients without adjuvant chemotherapy. External validation using The Cancer Genome Atlas-Pancreatic Adenocarcinoma cohort further supported the association between unfavorable prognosis and high SPARC expression. These findings suggest that stromal SPARC may serve as a meaningful prognostic biomarker and potential therapeutic target for pancreatic ductal adenocarcinoma. |
| Publish Date |
2025-11-14 00:56 |
| Citation |
<p>Yang HY, Chong JU, Jang M, Lee SH, Hwang HK, Lee WJ, Kang CM. Stromal secreted protein acidic and rich in cysteine expression: A potential target for improved prognosis in patients with pancreatic cancer. <i>World J Gastrointest Oncol</i> 2025; 17(11): 110704</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i11/110704.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i11.110704 |
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