| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Precision therapy guided by genotypic antibiotic resistance for Helicobacter pylori eradication: A prospective, randomized controlled trial
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan Xu, Jing-Wen Hao, Cong-Cong Min, Lin Yang, Cui-Ping Ma, Chao Shi, Tao Mao, Zi-Bin Tian, Tong Wang and Ya-Nan Yu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Qilu Health Outstanding Young Talent Cultivation Project |
QDFY-3839 |
|
| Corresponding Author |
Ya-Nan Yu, MD, Professor, Department of Gastroenterology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266000, Shandong Province, China. yananyu@qdu.edu.cn |
| Key Words |
Helicobacter pylori; Antibiotic resistance; Precision medicine; Eradication rate; First-line therapy |
| Core Tip |
Antibiotic resistance in Helicobacter pylori (H. pylori) has reduced the efficacy of traditional eradication regimens. This randomized controlled trial in northern China used rapid genotypic antibiotic susceptibility testing (G-AST) to guide first-line therapy by tailoring regimens according to detected resistance mutations, including tetracycline for dual-resistant strains. G-AST-guided therapy significantly improved eradication rates compared with standard bismuth quadruple therapy without increasing adverse events. These findings demonstrate the feasibility and clinical benefit of molecular-guided personalized treatment, offering a promising strategy to overcome antibiotic resistance in H. pylori infection. |
| Publish Date |
2025-11-13 06:51 |
| Citation |
<p>Xu Y, Hao JW, Min CC, Yang L, Ma CP, Shi C, Mao T, Tian ZB, Wang T, Yu YN. Precision therapy guided by genotypic antibiotic resistance for Helicobacter pylori eradication: A prospective, randomized controlled trial. <i>World J Gastroenterol</i> 2025; 31(42): 110717</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i42/110717.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i42.110717 |
