Publication Name	World Journal of Psychiatry
Manuscript ID	110719
Country	Qatar

Received	2025-06-13 03:31
Peer-Review Started	2025-06-13 03:31
To Make the First Decision
Return for Revision	2025-06-22 10:14
Revised	2025-06-25 10:58
Second Decision	2025-07-29 02:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-29 06:03
Articles in Press	2025-07-29 06:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-09-15 00:57
Publish the Manuscript Online	2025-09-26 08:18

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Psychiatry
Manuscript Type	Letter to the Editor
Article Title	Methodological reflections on a nutritional status-based nomogram for predicting cognitive impairment in elderly hypertensive patients
Manuscript Source	Invited Manuscript
All Author List	Abdul Rauf Khalid and Abdulqadir J Nashwan
ORCID	Author(s) ORCID Number Abdulqadir J Nashwan http://orcid.org/0000-0003-4845-4119
Funding Agency and Grant Number
Corresponding Author	Abdulqadir J Nashwan, Department of Nursing, Hamad Medical Corporation, Al Rayyan Road, Doha 3050, Qatar. anashwan@hamad.qa
Key Words	Cognitive impairment; Hypertension; Elderly patients; Nomogram; Biochemical markers; Reverse causality
Core Tip	This critique highlights key methodological limitations in Xu et al’s predictive model for cognitive impairment in elderly hypertensive patients. Chief concerns include the small validation sample, potential reverse causality due to the cross-sectional design, insufficient discussion of alkaline phosphatase as a biomarker, omission of key cognitive risk factors, and possible overfitting. We recommend external validation, longitudinal analysis, incorporation of psychosocial and genetic variables, and rigorous calibration to improve reliability and clinical applicability.
Publish Date	2025-09-26 08:18
Citation	<p>Khalid AR, Nashwan AJ. Methodological reflections on a nutritional status-based nomogram for predicting cognitive impairment in elderly hypertensive patients. <i>World J Psychiatry</i> 2025; 15(10): 110719</p>
URL	https://www.wjgnet.com/2220-3206/full/v15/i10/110719.htm
DOI	https://dx.doi.org/10.5498/wjp.v15.i10.110719

Full Article (PDF)	WJP-15-110719-with-cover.pdf
Manuscript File	110719_Auto_Edited_064903.docx
Answering Reviewers	110719-answering-reviewers.pdf
Audio Core Tip	110719-audio.mp4
Conflict-of-Interest Disclosure Form	110719-conflict-of-interest-statement.pdf
Copyright License Agreement	110719-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	110719-non-native-speakers.pdf
Peer-review Report	110719-peer-reviews.pdf
Scientific Misconduct Check	110719-scientific-misconduct-check.png
Scientific Editor Work List	110719-scientific-editor-work-list.pdf
CrossCheck Report	110719-crosscheck-report.pdf