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11/27/2025 7:53:52 AM | Browse: 3 | Download: 28
Publication Name World Journal of Hepatology
Manuscript ID 110725
Country Egypt
Received
2025-06-13 06:28
Peer-Review Started
2025-06-13 06:29
To Make the First Decision
Return for Revision
2025-06-26 08:07
Revised
2025-07-08 03:02
Second Decision
2025-09-02 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-09-02 06:46
Articles in Press
2025-09-02 06:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-10-31 13:05
Publish the Manuscript Online
2025-11-27 07:53
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Editorial
Article Title Essential phospholipids and enzyme-based staging in nonalcoholic fatty liver disease: A call to action
Manuscript Source Invited Manuscript
All Author List Ali Madian
ORCID
Author(s) ORCID Number
Ali Madian http://orcid.org/0000-0002-8322-7504
Funding Agency and Grant Number
Corresponding Author Ali Madian, Associate Professor, Consultant, MD, PhD, Department of Internal Medicine, Faculty of Medicine, Al-Azhar University-Assiut, Al Walideyah Al Bahreyah, Assiut 71524, Egypt. a.madian@azhar.edu.eg
Key Words Nonalcoholic fatty liver disease; Metabolic dysfunction-associated steatotic liver disease; Essential phospholipids; Liver enzymes; Noninvasive diagnostics; Ultrasonography
Core Tip The MANPOWER study demonstrated that Essentiale Forte N® reduces liver enzyme levels (alanine aminotransferase: 20-37 U/L, aspartate aminotransferase: 17-29 U/L, gamma-glutamyl transferase: 17-24 U/L, P < 0.001) and improves ultrasonography findings in patients with nonalcoholic fatty liver disease, with greater efficacy in severe cases. A liver enzyme-based algorithm offers 72.3% accuracy for noninvasive staging, prompting clinicians to adopt essential phospholipids and researchers to refine scalable diagnostics to address nonalcoholic fatty liver disease’s global burden.
Publish Date 2025-11-27 07:53
Citation <p>Madian A. Essential phospholipids and enzyme-based staging in nonalcoholic fatty liver disease: A call to action. <i>World J Hepatol</i> 2025; 17(11): 110725</p>
URL https://www.wjgnet.com/1948-5182/full/v17/i11/110725.htm
DOI https://dx.doi.org/10.4254/wjh.v17.i11.110725
Full Article (PDF) WJH-17-110725-with-cover.pdf
Manuscript File 110725_Auto_Edited_090825.docx
Answering Reviewers 110725-answering-reviewers.pdf
Audio Core Tip 110725-audio.mp4
Conflict-of-Interest Disclosure Form 110725-conflict-of-interest-statement.pdf
Copyright License Agreement 110725-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 110725-non-native-speakers.pdf
Peer-review Report 110725-peer-reviews.pdf
Scientific Misconduct Check 110725-scientific-misconduct-check.png
Scientific Editor Work List 110725-scientific-editor-work-list.pdf
CrossCheck Report 110725-crosscheck-report.pdf