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Articles Published Processes
12/26/2025 10:27:29 AM | Browse: 1 | Download: 1
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Received |
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2025-06-13 08:40 |
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Peer-Review Started |
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2025-06-13 08:41 |
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First Decision by Editorial Office Director |
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2025-07-14 07:06 |
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Return for Revision |
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2025-07-14 07:06 |
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Revised |
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2025-07-24 23:57 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-07 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-07 11:05 |
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Articles in Press |
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2025-11-07 11:05 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-18 02:14 |
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Publish the Manuscript Online |
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2025-12-26 10:27 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Targeting sirtuin 1/nuclear factor erythroid 2-related factor 2/tumor necrosis factor-ɑ pathway to modulate hepatic ischemia reperfusion-induced injury
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mina Thabet Kelleni, Walaa Yehia Abdelzaher, Marly Adly, Mina Ezzat Attya, Michael A Fawzy and Mohamed Abdellah Ibrahim |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mina Thabet Kelleni, Assistant Professor, MD, PhD, Department of Medical Pharmacology, College of Medicine, Minia University, Main Road Shalaby Land, Minia 61519, Egypt. mina.kelleni@mu.edu.eg |
| Key Words |
Hepatic ischemia reperfusion injury; Aprepitant; Sirtuin 1; Nuclear factor erythroid-2-related factor 2; Tumor necrosis factor alpha |
| Core Tip |
This study demonstrates that aprepitant, a neurokinin-1 receptor antagonist, exerts hepatoprotective effects in a rat model of hepatic ischemia reperfusion by modulating the sirtuin 1/nuclear factor erythroid-2-related factor 2/tumor necrosis factor alpha signaling pathway. Aprepitant significantly reduced hepatic enzyme elevation, oxidative stress parameters, inflammatory cytokines, and apoptosis markers, while enhancing the pluripotent capacity of sirtuin 1/nuclear factor erythroid-2-related factor 2 expression, highlighting its potential as a therapeutic agent to mitigate HIR-induced liver injury during major liver surgeries, as well as highlighting the significant therapeutic pharmacological potential while targeting this pathway by other current and future drugs. |
| Publish Date |
2025-12-26 10:27 |
| Citation |
Kelleni MT, Abdelzaher WY, Adly M, Attya ME, Fawzy MA, Ibrahim MA. Targeting sirtuin 1/nuclear factor erythroid 2-related factor 2/tumor necrosis factor-ɑ pathway to modulate hepatic ischemia reperfusion-induced injury. World J Hepatol 2025; 17(12): 110733 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i12/110733.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i12.110733 |
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