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Articles Published Processes
12/11/2025 8:20:57 AM | Browse: 93 | Download: 342
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Received |
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2025-06-16 10:01 |
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Peer-Review Started |
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2025-06-16 10:01 |
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First Decision by Editorial Office Director |
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2025-07-03 11:09 |
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Return for Revision |
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2025-07-04 01:43 |
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Revised |
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2025-07-08 08:35 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-17 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-17 07:07 |
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Articles in Press |
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2025-10-17 07:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-01 05:50 |
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Publish the Manuscript Online |
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2025-12-11 08:20 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Transient receptor potential melastatin 6 and transient receptor potential melastatin 6/7 antagonists suppress colon adenocarcinoma HT-29 cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Nattida Kampuang, Siriporn Chamniansawat, Pawin Pongkorpsakol, Supisara Treveeravoot and Narongrit Thongon |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science Research and Innovation Fund |
53/2567 |
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| Corresponding Author |
Narongrit Thongon, Associate Professor, PhD, Department of Medical Sciences, Faculty of Allied Health Sciences, Burapha University, 169 Long-Hard Bangsaen Road, Saensook, Muang 20131, Chonburi, Thailand. narongritt@buu.ac.th |
| Key Words |
Cancer stem cells; Cellular Mg2+ content; Colorectal cancer; Transient receptor potential melastatin 6/7; Transient receptor potential melastatin 6 |
| Core Tip |
This study demonstrated that colorectal cancer (CRC) spheroids (SPs) exhibited significantly increased membrane expression and phosphorylation of transient receptor potential melastatin (TRPM) 6 and TRPM6/7 channels, which enhanced magnesium (Mg2+) influx and promoted intracellular Mg2+ accumulation. However, selective TRPM6 and TRPM6/7 inhibitors markedly suppressed Mg2+ influx, SP formation, cell viability, and migration and impaired cancer stem-like properties. These findings highlight the critical role of TRPM6/TRPM7-mediated Mg2+ transport in CRC progression and emphasize the potential of these channels as therapeutic targets for CRC SP elimination. |
| Publish Date |
2025-12-11 08:20 |
| Citation |
Kampuang N, Chamniansawat S, Pongkorpsakol P, Treveeravoot S, Thongon N. Transient receptor potential melastatin 6 and transient receptor potential melastatin 6/7 antagonists suppress colon adenocarcinoma HT-29 cells. World J Gastrointest Oncol 2025; 17(12): 110736 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i12/110736.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i12.110736 |
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