| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Minireviews |
| Article Title |
Biomarkers innovation in urinary tract infections: Insights into pathophysiology, antibiotic resistance, and clinical applications
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Swathi Pandey, Arul Senghor Kadalangudi Aravaanan, Emmanuel Bhaskar and Santhi Silambanan |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Santhi Silambanan, MD, Professor, Department of Biochemistry, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai 600116
India, Chennai 600116, Tamil Nādu, India. santhisilambanan@sriramachandra.edu.in |
| Key Words |
Urinary tract infection; Pathogens; Diagnosis; antibiotic sensitivity; Host-derived biomarkers; Pathogen-derived biomarkers; Point-of-care testing; Sustainable development goals 3; Sustainable development goals 8 |
| Core Tip |
Urinary tract infections (UTIs) are prevalent and often require timely diagnosis to prevent complications. The emerging urinary biomarkers, including neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, interleukin (IL)-6, IL-8, heparin-binding protein, procalcitonin, lipopolysaccharide-binding protein, xanthine oxidase, cell-free DNA, and transrenal DNA, have shown potential in identifying infection severity, organ dysfunction, and antibiotic resistance. The review further examines how integrating these biomarkers with advanced biosensor-based diagnostic tools can enhance diagnostic sensitivity, facilitate point-of-care testing, and improve clinical outcomes. The review also underscores the importance of validating and standardizing biomarker-based diagnostics to bridge laboratory innovations with clinical application, ultimately supporting more accurate, rapid, and personalized UTI management. |
| Publish Date |
2025-12-23 08:03 |
| Citation |
Pandey S, Aravaanan ASK, Bhaskar E, Silambanan S. Biomarkers innovation in urinary tract infections: Insights into pathophysiology, antibiotic resistance, and clinical applications. World J Nephrol 2025; 14(4): 110749 |
| URL |
https://www.wjgnet.com/2220-6124/full/v14/i4/110749.htm |
| DOI |
https://dx.doi.org/10.5527/wjn.v14.i4.110749 |
