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Articles Published Processes
12/19/2025 8:32:44 AM | Browse: 3 | Download: 24
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Received |
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2025-06-16 10:03 |
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Peer-Review Started |
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2025-06-16 10:03 |
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First Decision by Editorial Office Director |
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2025-07-02 08:50 |
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Return for Revision |
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2025-07-02 08:50 |
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Revised |
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2025-07-12 09:10 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-03 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-03 04:12 |
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Articles in Press |
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2025-11-03 04:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-08 06:03 |
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Publish the Manuscript Online |
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2025-12-19 08:32 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Ferula assafoetida induced colon cancer cells differentiation through JNK/MAPK signalling pathway activation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hani M Abdelsalam, Aya M Abdelghany, Wafaa A Ahmed, Abdelaziz Abbas Diab and Mona S Abdellateif |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mona S Abdellateif, Department of Cancer Biology, National Cancer Institute, Cairo University, 1 Fom Elkhaligue, Cairo 11796, Al Qāhirah, Egypt. mona.sayed@nci.cu.edu.eg |
| Key Words |
Ferula assafoetida; Colorectal cancer; Differentiation; JNK; MAPK; Alkaline phosphatase |
| Core Tip |
Ferula assafoetida (F. assafoetida) could be considered a potential differentiating agent for colon cancer cells through increasing the alkaline phosphatase activity, as well as upregulation of JNK and MAPK gene expression. Additionally, it has important implications for cancer therapy through arresting cells in the sub-G1 phase, inducing cytotoxicity, DNA fragmentation, and apoptosis in the cancer cells compared to those treated with sodium butyrate (NaBT), and untreated control cells. Moreover, F. assafoetida has a protective impact against the cellular oxidative stress revealed by the significant increase in the total antioxidant concentration and glutathione level, while a significant decrease in the malondialdehyde levels in the Caco cells compared to cells treated with NaBT, and the untreated control cells. F. assafoetida is a useful, efficient, inexpensive, and novel therapeutic medicinal herps for colon cancer patients. |
| Publish Date |
2025-12-19 08:32 |
| Citation |
Abdelsalam HM, Abdelghany AM, Ahmed WA, Diab AA, Abdellateif MS. Ferula assafoetida induced colon cancer cells differentiation through JNK/MAPK signalling pathway activation. World J Exp Med 2025; 15(4): 110757 |
| URL |
https://www.wjgnet.com/2220-315x/full/v15/i4/110757.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i4.110757 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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