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Articles Published Processes
10/27/2025 10:57:53 AM | Browse: 100 | Download: 112
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Received |
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2025-06-18 09:53 |
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Peer-Review Started |
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2025-06-18 09:53 |
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First Decision by Editorial Office Director |
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2025-06-26 08:08 |
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Return for Revision |
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2025-06-26 08:08 |
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Revised |
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2025-07-23 15:30 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-24 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-24 06:06 |
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Articles in Press |
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2025-09-24 06:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-16 08:22 |
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Publish the Manuscript Online |
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2025-10-27 10:57 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Clinical significance and pathogenic mechanisms of fatigue in metabolic dysfunction-associated steatotic liver disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Anna F Sheptulina, Julia A Golubeva, Anton R Kiselev and Oxana M Drapkina |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Russian Science Foundation |
23-45-10030 |
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| Corresponding Author |
Anton R Kiselev, Head, Professor, Coordinating Center for Fundamental Research, National Medical Research Center for Therapy and Preventive Medicine, Petroverigsky Lane, 10, Building 3, Moscow 101990, Russia. antonkis@list.ru |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; Fatigue; Depression; Inflammation; Neuroinflammation; Neurotoxicity; Mitochondrial dysfunction; Hyperammoniemia; Muscle dysfunction |
| Core Tip |
Fatigue is a frequent but underrecognized symptom in metabolic dysfunction-associated steatotic liver disease (MASLD). This review presents an integrative perspective on fatigue as a systemic manifestation of MASLD, distinct from but overlapping with depression. Central (e.g., neuroinflammation, brain-liver axis dysfunction) and peripheral (e.g., sarcopenia, mitochondrial dysfunction) mechanisms are discussed. Current evidence on exercise, pharmacologic, and behavioral interventions is summarized. Recognizing fatigue as an active factor influencing lifestyle and outcomes may guide new therapeutic strategies and clinical trial designs in MASLD. |
| Publish Date |
2025-10-27 10:57 |
| Citation |
Sheptulina AF, Golubeva JA, Kiselev AR, Drapkina OM. Clinical significance and pathogenic mechanisms of fatigue in metabolic dysfunction-associated steatotic liver disease. World J Hepatol 2025; 17(10): 110848 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i10/110848.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i10.110848 |
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