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Articles Published Processes
12/24/2025 9:56:52 AM | Browse: 116 | Download: 237
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Received |
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2025-06-17 02:05 |
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Peer-Review Started |
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2025-06-17 02:05 |
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First Decision by Editorial Office Director |
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2025-07-08 07:06 |
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Return for Revision |
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2025-07-08 07:06 |
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Revised |
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2025-07-17 00:29 |
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Publication Fee Transferred |
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2025-07-18 14:00 |
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Second Decision by Editor |
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2025-11-03 07:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-03 07:46 |
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Articles in Press |
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2025-11-03 07:46 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-11 03:43 |
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Publish the Manuscript Online |
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2025-12-24 09:56 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
Pentadecanoic acid (C15:0) and cardiovascular disease: A narrative review
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Joseph Mercola |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Joseph Mercola, Researcher, Independent Researcher, Midwestern University, 555 31st St, Downers Grove, IL 60515, United States. drm@mercola.com |
| Key Words |
Pentadecanoic acid; Cardiovascular disease; Odd-chain saturated fatty acids; Cardiometabolic health; Inflammation; Insulin sensitivity; Mitochondrial function; Dairy fat |
| Core Tip |
Pentadecanoic acid (C15:0), an odd-chain saturated fat concentrated in grass-fed dairy, is increasingly recognized as a “good” saturated fat with cardioprotective potential. Prospective cohorts and a recent meta-analysis show that individuals in the highest C15:0 quintile experience 12%-25% fewer cardiovascular events and approximately 14% less incident type 2 diabetes. Mechanistic studies reveal that C15:0 activates peroxisome proliferator-activated receptors alpha and delta and AMP-activated protein kinase, lowers low-density lipoprotein cholesterol and interleukin-6 and tumor necrosis factor α-driven inflammation, enhances insulin sensitivity, and repairs mitochondrial-endothelial function - findings that prompt calls to test dietary or supplemental C15:0 in randomized trials and to rethink blanket saturated-fat limits. |
| Publish Date |
2025-12-24 09:56 |
| Citation |
Mercola J. Pentadecanoic acid (C15:0) and cardiovascular disease: A narrative review. World J Cardiol 2025; 17(12): 110861 |
| URL |
https://www.wjgnet.com/1949-8462/full/v17/i12/110861.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v17.i12.110861 |
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