| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Protective effects of treprostinil and ischemic preconditioning on hepatic ischemia-reperfusion injury and biomarkers in experimental study in rats
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Christina Mouratidou, Efstathios T Pavlidis, Georgios Katsanos, Serafeim-Chrysovalantis Kotoulas, Maria Papaioannou, Georgios Tsoulfas, Emmanouela Apostolopoulou, Georgia D Brellou, Ioannis N Galanis and Theodoros E Pavlidis |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Theodoros E Pavlidis, MD, PhD, Professor, The Second Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr |
| Key Words |
Hepatic ischemia-reperfusion injury; Liver surgery and transplantation; Oxidative stress; Prostaglandins; Prostacyclin; Treprostinil; Ischemic preconditioning |
| Core Tip |
Hepatic ischemia-reperfusion injury is a serious condition that causes oxidative stress with a systemic inflammatory response. In addition to the liver, it may cause damage to remote organs, particularly the myocardium, with disastrous results. Consequently, its prevention is crucial, especially in liver surgery and transplantation. This experimental preclinical study in rats evaluated the cytoprotective effect of treprostinil, compared with that of ischemic preconditioning, on the liver and heart and assessed clearly useful biomarkers for better understanding the pathophysiology of systemic manifestations, thus opening new future perspectives for the further design of clinical trials assessing treprostinil efficacy. |
| Publish Date |
2025-11-25 11:05 |
| Citation |
Mouratidou C, Pavlidis ET, Katsanos G, Kotoulas SC, Papaioannou M, Tsoulfas G, Apostolopoulou E, Brellou GD, Galanis IN, Pavlidis TE. Protective effects of treprostinil and ischemic preconditioning on hepatic ischemia-reperfusion injury and biomarkers in experimental study in rats. World J Gastrointest Surg 2025; 17(11): 110864 |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i11/110864.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i11.110864 |
