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Articles Published Processes
12/19/2025 8:32:38 AM | Browse: 2 | Download: 1
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Received |
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2025-06-18 06:49 |
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Peer-Review Started |
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2025-06-18 06:49 |
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First Decision by Editorial Office Director |
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2025-06-24 11:04 |
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Return for Revision |
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2025-06-24 11:04 |
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Revised |
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2025-06-26 11:45 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-19 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-19 08:07 |
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Articles in Press |
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2025-09-19 08:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-28 09:28 |
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Publish the Manuscript Online |
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2025-12-19 08:32 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Chronotherapeutic optimization of radioactive iodine therapy in differentiated thyroid cancer: The rationale for evening administration
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Georgios Meristoudis, Christos Savvidis and Ioannis Ilias |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ioannis Ilias, Director, MD, PhD, Department of Endocrinology, Hippocration General Hospital, No. 63 Evrou Street, Athens GR-11527, Greece. iiliasmd@yahoo.com |
| Key Words |
Thyroid cancer; Radioactive iodine; Thyroid-stimulating hormone; Sodium-iodide symporter; Circadian rhythm; Chronotherapy; Treatment |
| Core Tip |
Radioactive iodine (RAI) therapy is central to differentiated thyroid cancer management, relying on thyroid-stimulating hormone (TSH)-driven sodium-iodide symporter activity. Current protocols elevate TSH but overlook its circadian peak overnight. Aligning RAI administration with this peak via evening dosing may enhance iodine uptake, improve efficacy, reduce exposure, and optimize workflow. Preclinical evidence supports this chronotherapeutic approach, although clinical data are lacking. This review synthesizes existing evidence and proposes timed RAI administration as a novel strategy warranting prospective evaluation. |
| Publish Date |
2025-12-19 08:32 |
| Citation |
Meristoudis G, Savvidis C, Ilias I. Chronotherapeutic optimization of radioactive iodine therapy in differentiated thyroid cancer: The rationale for evening administration. World J Exp Med 2025; 15(4): 110893 |
| URL |
https://www.wjgnet.com/2220-315x/full/v15/i4/110893.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i4.110893 |
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