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12/19/2025 8:32:41 AM | Browse: 3 | Download: 13
Publication Name World Journal of Experimental Medicine
Manuscript ID 110936
Country Türkiye
Received
2025-06-19 05:56
Peer-Review Started
2025-06-19 05:57
First Decision by Editorial Office Director
2025-07-18 07:29
Return for Revision
2025-07-18 07:29
Revised
2025-07-27 21:23
Publication Fee Transferred
Second Decision by Editor
2025-10-24 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-10-24 11:55
Articles in Press
2025-10-24 11:55
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-12-08 02:32
Publish the Manuscript Online
2025-12-19 08:32
ISSN 2220-315x (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Dermatology
Manuscript Type Systematic Reviews
Article Title Efficacy of beta-blockers in the treatment of hematidrosis: A systematic review
Manuscript Source Invited Manuscript
All Author List Ahmet Alperen Palabiyik
ORCID
Author(s) ORCID Number
Ahmet Alperen Palabiyik http://orcid.org/0000-0002-8199-390X
Funding Agency and Grant Number
Corresponding Author Ahmet Alperen Palabiyik, Lecturer, PhD, Department of Nursing, Department of Nursing, Faculty of Health Sciences, Ardahan University, Çamlıçatak, Ardahan 75002, Turkey, <italic>Correspondence to</italic>: Dr Ahmet Alperen Palabiyik, Department of Nursing, Faculty of Health Sciences, Ardahan University, Yenisey Campus, Çamlıçatak, Ardahan 75002, Turkey, E-mail: <email>ahmetalperenpalabiyik@ardahan.edu.tr</email>, Ardahan 75000, Türkiye. ahmetalperenpalabiyik@ardahan.edu.tr
Key Words Hematidrosis; Beta-blockers; Propranolol; Adrenergic inhibition; Psychogenic bleeding; Stress-related disorders; Sympathetic overactivation
Core Tip Hematidrosis is an extremely rare condition characterized by spontaneous bleeding through intact skin, often triggered by emotional stress. This systematic review evaluates the efficacy and safety of beta-blockers, particularly propranolol, in managing hematidrosis. The findings indicate that propranolol can significantly reduce symptom frequency and severity, especially when combined with psychotherapy. By focusing solely on clinical studies involving beta-blocker use, this review bridges a critical gap in the literature and highlights the need for standardized treatment protocols and controlled clinical trials. The results support a multidisciplinary approach targeting both physiological and psychological triggers.
Publish Date 2025-12-19 08:32
Citation

Palabiyik AA. Efficacy of beta-blockers in the treatment of hematidrosis: A systematic review. World J Exp Med 2025; 15(4): 110936

URL https://www.wjgnet.com/2220-315x/full/v15/i4/110936.htm
DOI https://dx.doi.org/10.5493/wjem.v15.i4.110936
Full Article (PDF) WJEM-15-110936-with-cover.pdf
PRISMA 2009 Checklist 110936-PRISMA-2009-Checklist.pdf
Manuscript File 110936_Auto_Edited_031728.docx
Answering Reviewers 110936-answering-reviewers.pdf
Audio Core Tip 110936-audio.mp3
Biostatistics Review Certificate 110936-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 110936-conflict-of-interest-statement.pdf
Copyright License Agreement 110936-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 110936-non-native-speakers.pdf
Peer-review Report 110936-peer-reviews.pdf
Scientific Misconduct Check 110936-scientific-misconduct-check.png
Scientific Editor Work List 110936-scientific-editor-work-list.pdf
CrossCheck Report 110936-crosscheck-report.pdf