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Articles Published Processes
12/22/2025 7:43:01 AM | Browse: 13 | Download: 48
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Received |
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2025-06-20 02:00 |
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Peer-Review Started |
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2025-06-20 02:00 |
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First Decision by Editorial Office Director |
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2025-06-30 06:53 |
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Return for Revision |
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2025-06-30 06:53 |
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Revised |
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2025-07-13 21:30 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-21 03:05 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-22 05:18 |
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Articles in Press |
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2025-10-22 05:18 |
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Edit the Manuscript by Language Editor |
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2025-10-25 20:29 |
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Typeset the Manuscript |
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2025-12-15 03:46 |
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Publish the Manuscript Online |
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2025-12-22 07:43 |
| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Colorectal cancer metastasis to the brain: A scoping review of incidence, treatment, and outcomes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hunter J Hutchinson, Melanie Gonzalez, Diana Feier, Colin E Welch and Brandon Lucke-Wold |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hunter J Hutchinson, College of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, United States. hutchinsonhunter@ufl.edu |
| Key Words |
Colorectal cancer; Brain tumor; Metastasis; Carcinoembryonic antigen; Kirsten rat sarcoma viral oncogene homolog; Human epidermal growth factor receptor 2; Whole-brain radiotherapy; Stereotactic ablative radiotherapy; Neurosurgery |
| Core Tip |
Brain metastases (BM) from colorectal cancer are becoming more common as overall survival increases. Socioeconomic factors are associated with worse prognosis in colorectal cancer BM but not an increased incidence. Primary colorectal tumor characteristics that increase incidence of brain metastasis and have worse prognosis are right-sidedness, rectal origin, adenocarcinoma histology, and having high carcinoembryonic antigen. Kirsten rat sarcoma viral oncogene homolog and human epidermal growth factor 2 mutated colorectal tumors have higher incidence of BM but inconclusive prognostic value. Patients with smaller, less numerous BM can be treated with stereotactic ablative radiotherapy while patients with larger, more numerous tumors should receive whole-brain radiotherapy and surgical resection. |
| Publish Date |
2025-12-22 07:43 |
| Citation |
Hutchinson HJ, Gonzalez M, Feier D, Welch CE, Lucke-Wold B. Colorectal cancer metastasis to the brain: A scoping review of incidence, treatment, and outcomes. World J Gastrointest Pathophysiol 2025; 16(4): 110961 |
| URL |
https://www.wjgnet.com/2150-5330/full/v16/i4/110961.htm |
| DOI |
https://dx.doi.org/10.4291/wjgp.v16.i4.110961 |
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