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Articles Published Processes
12/23/2025 8:03:19 AM | Browse: 12 | Download: 66
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Received |
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2025-06-20 02:26 |
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Peer-Review Started |
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2025-06-20 02:26 |
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First Decision by Editorial Office Director |
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2025-07-30 08:39 |
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Return for Revision |
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2025-07-30 08:39 |
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Revised |
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2025-07-30 15:59 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-17 02:51 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-17 07:47 |
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Articles in Press |
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2025-09-17 07:47 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-01 07:11 |
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Publish the Manuscript Online |
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2025-12-23 08:03 |
| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Minireviews |
| Article Title |
Beneficial effect of sodium-glucose cotransporter 2 inhibitors on kidney function can be just a mirage
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| Manuscript Source |
Invited Manuscript |
| All Author List |
María M Adeva-Andany |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
María M Adeva-Andany, MD, PhD, Nephrology, Hospital Juan Cardona, Pardo Bazán, Ferrol 15406, Spain. madevaa@yahoo.com |
| Key Words |
Sodium-glucose cotransporter-2 inhibitors; Estimated glomerular filtration rate; Glomerular hyperfiltration; osmotic diuresis; Glucosuria; Skeletal muscle mass; Serum creatinine-based estimation of glomerular filtration rate; Kidney function overestimation |
| Core Tip |
Sodium-glucose cotransporter-2 (SGLT2) inhibitors increase long-term serum creatinine-based estimated glomerular filtration rate (GFR), but this effect may not represent a kidney protective effect. Subjects undergoing osmotic diuresis exhibit glomerular hyperfiltration. In patients receiving SGLT2 inhibitors, the elevated estimated GFR may reflect an adaptive response to osmotic diuresis rather than an improvement of kidney function. In addition, loss of skeletal muscle mass has been consistently associated with use of SGLT2 inhibitors. In patients with reduced muscle mass, serum creatinine-based estimation of GFR produces a deceptive increase of estimated GFR. In patients receiving SGLT2 inhibitors, increased estimated GFR may represent an overestimation of the factual kidney function rather than an actual improvement. |
| Publish Date |
2025-12-23 08:03 |
| Citation |
Adeva-Andany MM. Beneficial effect of sodium-glucose cotransporter 2 inhibitors on kidney function can be just a mirage. World J Nephrol 2025; 14(4): 110990 |
| URL |
https://www.wjgnet.com/2220-6124/full/v14/i4/110990.htm |
| DOI |
https://dx.doi.org/10.5527/wjn.v14.i4.110990 |
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