| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Differential gene-expression profiling of gastric intraepithelial neoplasia and early-stage adenocarcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xue Xu, Yu Liu, Wei-Xun Zhou, Ying-Cai Ma, Gui-Jun Fei, Ning An, Yuan Li, Xi Wu, Fang Yao, Shu-Jun Cheng, Lin Feng and Xing-Hua Lu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Public-Funded Projects in the Health Industry |
200902002 |
|
| Corresponding Author |
Correspondence to: Xing-hua Lu, Shuai Fu Yuan 1, Dongcheng District, Beijing 100730, P.R. China. lxhbj2000@aliyun.com, Tel(Fax): +86-10-69155016; Correspondence to:Lin Feng, 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, PR China. fenglin@cicams.ac.cn, Tel(Fax): +86-10-87787363 |
| Key Words |
Gastric early-stage adenocarcinoma; High-and low-grade intraepithelial neoplasia; G0/G1 switch 2; Whole genome expression microarray; Quantitative real-time PCR; Immunohistochemical staining |
| Core Tip |
This is the first study to perform a comprehensive detection of the gene expression profilings of gastric low-grade and high-grade intraepithelial neoplasia and early-stage adenocarcinoma. This study collected precious samples to report the clear distinction of the gene expression profiles between gastric low-grade and high-grade intraepithelial neoplasia, thus providing molecular evidence for their different clinical application. The characteristic upregulated genes during gastric early carcinogenesis were involved in metabolism and the immune response and nuclear factor-κB (NF-κB) pathway, whose expression was validated in independent samples through real-time TaqMan? PCR and immunohistochemical staining. |
| Publish Date |
2014-12-20 19:42 |
| Citation |
Xu X, Feng L, Liu Y, Zhou WX, Ma YC, Fei GJ, An N, Li Y, Wu X, Yao F, Cheng SJ, Lu XH. Differential gene expression profiling of gastric intraepithelial neoplasia and early-stage adenocarcinoma. World J Gastroenterol 2014; 20(47): 17883-17893 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i47/17883.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i47.17883 |
