Publication Name	World Journal of Gastroenterology
Manuscript ID	11101
Country	China

Received	2014-05-05 08:57
Peer-Review Started	2014-05-05 19:28
First Decision by Editorial Office Director
Return for Revision	2014-06-04 14:35
Revised	2014-06-05 11:49
Publication Fee Transferred
Second Decision by Editor	2014-06-17 09:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-06-17 09:56
Articles in Press	2014-06-17 10:15
Edit the Manuscript by Language Editor	2014-07-01 16:36
Typeset the Manuscript	2014-12-15 18:07
Publish the Manuscript Online	2014-12-20 19:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Differential gene-expression profiling of gastric intraepithelial neoplasia and early-stage adenocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Xue Xu, Yu Liu, Wei-Xun Zhou, Ying-Cai Ma, Gui-Jun Fei, Ning An, Yuan Li, Xi Wu, Fang Yao, Shu-Jun Cheng, Lin Feng and Xing-Hua Lu
Funding Agency and Grant Number	Funding Agency Grant Number Public-Funded Projects in the Health Industry 200902002
Corresponding Author	Correspondence to: Xing-hua Lu, Shuai Fu Yuan 1, Dongcheng District, Beijing 100730, P.R. China. lxhbj2000@aliyun.com, Tel(Fax): +86-10-69155016; Correspondence to:Lin Feng, 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, PR China. fenglin@cicams.ac.cn, Tel(Fax): +86-10-87787363
Key Words	Gastric early-stage adenocarcinoma; High-and low-grade intraepithelial neoplasia; G0/G1 switch 2; Whole genome expression microarray; Quantitative real-time PCR; Immunohistochemical staining
Core Tip	This is the first study to perform a comprehensive detection of the gene expression profilings of gastric low-grade and high-grade intraepithelial neoplasia and early-stage adenocarcinoma. This study collected precious samples to report the clear distinction of the gene expression profiles between gastric low-grade and high-grade intraepithelial neoplasia, thus providing molecular evidence for their different clinical application. The characteristic upregulated genes during gastric early carcinogenesis were involved in metabolism and the immune response and nuclear factor-κB (NF-κB) pathway, whose expression was validated in independent samples through real-time TaqMan? PCR and immunohistochemical staining.
Publish Date	2014-12-20 19:42
Citation	Xu X, Feng L, Liu Y, Zhou WX, Ma YC, Fei GJ, An N, Li Y, Wu X, Yao F, Cheng SJ, Lu XH. Differential gene expression profiling of gastric intraepithelial neoplasia and early-stage adenocarcinoma. World J Gastroenterol 2014; 20(47): 17883-17893
URL	http://www.wjgnet.com/1007-9327/full/v20/i47/17883.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i47.17883

Full Article (PDF)	WJG-20-17883.pdf
Full Article (Word)	WJG-20-17883.doc
Manuscript File	11101-Review.docx
Answering Reviewers	11101-Answering reviewers.pdf
Copyright License Agreement	11101-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140504205540.jpg
Non-Native Speakers of English Editing Certificate	11101-Language certificate.pdf
Peer-review Report	11101-Peer reviews.pdf
Scientific Misconduct Check	11101-CrossCheck.jpg
Scientific Editor Work List	11101-Scientific editor work list.pdf