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Articles Published Processes
12/22/2025 7:43:01 AM | Browse: 7 | Download: 32
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Received |
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2025-06-23 13:22 |
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Peer-Review Started |
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2025-06-23 13:22 |
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First Decision by Editorial Office Director |
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2025-07-17 10:18 |
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Return for Revision |
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2025-07-17 10:18 |
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Revised |
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2025-07-31 05:49 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-03 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-04 02:56 |
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Articles in Press |
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2025-11-04 02:56 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-15 02:43 |
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Publish the Manuscript Online |
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2025-12-22 07:43 |
| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Pathophysiology of depression and anxiety in metabolic dysfunction-associated steatotic liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sampada, Mohammad Naseem, Mehul Solanki, Ragini Sharma, Carol Singh and Aalam Sohal |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Aalam Sohal, MD, Gastroenterology and Hepatology, Creighton University School of Medicine, 3216 NE 45th Pl Suite 212, Phoenix, AZ 85012, United States. aalamsohal@gmail.com |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; Non-alcoholic fatty liver disease; Depression; Anxiety; Hypothalamic-pituitary-adrenal axis; Gut-liver-brain axis; Neuroinflammation; Cytokines |
| Core Tip |
Metabolic dysfunction-associated steatotic liver disease is associated with mood disorders such as depression and anxiety through shared pathophysiological pathways. This review links systemic inflammation, hypothalamic-pituitary-adrenal axis dysregulation, gut dysbiosis, and neurotransmitter imbalances as mediators of this bidirectional relationship. We highlight how overlapping risk factors such as insulin resistance, obesity, sarcopenia, poor sleep, and physical inactivity exacerbate both the disease processes. Recognizing the mental health burden allows for improved patient outcomes and supports a holistic, lifestyle-focused treatment model that addresses both physical and mental health. |
| Publish Date |
2025-12-22 07:43 |
| Citation |
Sampada, Naseem M, Solanki M, Sharma R, Singh C, Sohal A. Pathophysiology of depression and anxiety in metabolic dysfunction-associated steatotic liver disease. World J Gastrointest Pathophysiol 2025; 16(4): 111029 |
| URL |
https://www.wjgnet.com/2150-5330/full/v16/i4/111029.htm |
| DOI |
https://dx.doi.org/10.4291/wjgp.v16.i4.111029 |
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